胡思雄 张钲

    [摘要] 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是成人中越来越常见的一种慢性睡眠呼吸障碍性疾病。睡眠呼吸障碍对心血管系统有重要的作用，OSAHS合并冠心病的患者越来越多，然而OSAHS对于冠心病的发生发展仍不明确，治疗上仍存在较大的争议。本文针对OSAHS与冠心病的发病、严重程度以及预后情况等方面的相关研究进展进行综述。

    [关键词] 阻塞性睡眠呼吸暂停低通气综合征;间歇性缺氧;呼吸暂停低通气指数;冠心病

    [中图分类号] R766.43? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)02(a)-0052-04

    [Abstract] Obstructive sleep apnea hypopnea syndrome (OSAHS) is a chronic sleep disordered breathing disease which is increasingly common in adults. Sleep-disordered breathing plays an important role in the cardiovascular system， and OSAHS patients with coronary heart disease are also increasing. However， OSAHS is still unclear about the occurrence and development of coronary heart disease， and still considerable controversy in treatment. This article reviews the progress on the incidence， severity and prognosis of OSAHS and coronary heart disease.

    [Key words] Obstructive sleep apnea hypopnea syndrome; Intermittent hypoxia; Apnea-hypopnea index; Coronary heart disease

    阻塞性睡眠呼吸暂停低通气综合征(OSAHS)指患者在夜间睡眠过程中反复出现阻塞性睡眠呼吸暂停和/或低通气，导致慢性间歇性缺氧(CIH)、高碳酸血症以及睡眠中断，使机体发生一系列病理生理改变的临床综合征 ......