达古拉 谢先达 王静

    [摘要] 间充质干细胞(MSCs)具有自我更新能力和多向分化潜能，在免疫调节、控制炎症和修复软骨破坏等方面有重要作用。MSCs产生大量可溶性膜结合因子，其中一些可抑制免疫应答，诱导免疫耐受，发挥重要的免疫调节作用。由于MSCs的生物学特性和免疫调节作用，在动物试验和临床研究中均证实了MSCs治疗类风湿关节炎的有效性与安全性。本文针对MSCs的功能特点和治疗类风湿关节炎方面的相关研究进展进行简要综述。

    [关键词] 间充质干细胞;类风湿关节炎;治疗;免疫调节

    [中图分类号] R593.22? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)02(c)-0040-04

    [Abstract] Mesenchymal stem cells (MSCs) have self-renewal ability and multi-directional differentiation potential， and they play an important role in immune regulation， inflammation control and cartilage destruction. MSCs produce a large number of soluble membrane-binding factors， some of which inhibit immune responses， induce immune tolerance， and exert important immunomodulatory effects. Due to the biological characteristics and immunomodulatory effects of MSCs， the efficacy and safety of MSCs in the treatment of rheumatoid arthritis have been confirmed in animal experiments and clinical studies in recent years. This article briefly reviews the functional characteristics of MSCs and the related research progress in the treatment of rheumatoid arthritis. ......