梁颖 许源

    [摘要] 胶质瘤是常见的中枢神经系统原发性肿瘤，临床治疗普遍采用手术切除后放化疗，但其治疗效果不佳。氧化石墨烯纳米载体具有优良的理化性质，主要通过药物化疗、免疫疗法和光热疗法三种途径在胶质瘤的治疗中发挥重要作用。本文对近年来氧化石墨烯纳米载体在胶质瘤治疗中的研究作一综述，以期为胶质瘤的生物治疗提供参考依据和新思路。

    [关键词] 氧化石墨烯;胶质瘤;纳米载体

    [中图分类号] R739.41? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)03(a)-0051-04

    [Abstract] Glioma is a common primary tumor of the central nervous system， radiotherapy and chemotherapy after surgical resection are commonly used in clinical treatment， but the therapeutic effect is not good. Graphene oxide nanocarriers have excellent physicochemical propertie and play an important role in the treatment of glioma mainly through drug chemotherapy， immunotherapy and photothermal therapy. This paper reviews the recent research progress of graphene oxide nanocarrier in the treatment of glioma in order to provide reference and new ideas for the biological treatment of glioma.

    [Key words] Graphene oxide; Glioma; Nanocarrier

    胶质瘤是常见的中枢神经系统原发性肿瘤，由人脑星形胶质细胞产生，约占颅内肿瘤的27%，发病率较高且易转移，是最具侵袭性和致命性的恶性肿瘤之一[1]。在所有胶质瘤中，胶质母细胞瘤(glioblastoma，GBM)最为常见[2]。目前，GBM的标准治疗采用手术切除后放化疗，由于GBM呈现浸润性生长，手术不易完全切除 ......