李芳芳 张琪

    [摘要] 血管内皮的受损程度与高血压等心血管疾病的发展进程密切相关。高血压、冠心病以及动脉粥样硬化等多种心血管疾病均会出现不同程度的血管内皮损伤，保护损伤的内皮细胞是心血管疾病防治的关键。川芎嗪是从中草药川芎中提取的一种生物碱，具有生物活性和多种药理作用。其药理作用包括延缓内皮细胞凋亡、促进血管新生、抗炎、抗氧化等，可用于治疗高血压病引起的血管结构和功能的改变。本文综述了川芎嗪抗高血压病血管内皮损伤的作用机制及其研究进展，为川芎嗪治疗心脑血管病的临床应用提供科学依据。

    [关键词] 川芎嗪;血管内皮损伤;血管新生;氧化应激

    [中图分类号] R965? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)03(b)-0025-04

    [Abstract] The degree of vascular endothelial injury is closely related to the development of cardiovascular diseases such as hypertension. Many kinds of cardiovascular diseases， such as hypertension， coronary heart disease and atherosclerosis， will present different degrees of vascular endothelial injury， and the protection of injured endothelial cells is the key to the prevention and treatment of cardiovascular diseases. Tetramethylpyrazine is a kind of alkaloid extracted from Chinese herbal medicine Ligusticum chuanxiong Hort.. It has biological activity and many pharmacological effects. Its pharmacological effects include， delaying endothelial cell apoptosis， promoting angiogenesis， anti-inflammatory， antioxidant ......