周艳丽 许剑怡 王宏娟

    [摘要] 虫草素是从蛹虫草中分离的一种核苷类抗生素，具有多种生物活性，如抗菌、抗病毒、抗炎、免疫调节、抗肿瘤、降糖降脂和抗衰老等。虫草素对肺部、肝脏、肾脏和胃部等疾病有一定的治疗作用，也可以作为化妆品和保健品原料，还可以用于畜牧业。随着研究的逐步深入，虫草素的药理作用渐渐被挖掘，其作用机制也愈发清晰。本文总结了近些年来虫草素的药理作用研究及其应用，为后续更加深入地研究虫草素的药理作用和应用奠定了基础。

    [关键词] 虫草素;抗炎;抗肿瘤;免疫调节;降糖降脂;抗衰老;应用前景

    [中图分类号] R96? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)03(b)-0039-04

    [Abstract] Cordycepin is a nucleoside antibiotic isolated from Cordyceps militaris， which has a variety of biological activities， such as antibacterial， antiviral， anti-inflammatory， immune regulation， anti-tumor， hypoglycemic and anti-aging， etc. Cordycepin has a certain therapeutic effect on lung， liver， kidney， stomach and other diseases. It can also be used as cosmetics， health products and animal husbandry. With the deepening of research， the pharmacological effect of cordycepin has been gradually explored， and its mechanism has become increasingly clear. In this paper， we summarize the research and application of cordycepin in recent years， which lays a foundation for further study of cordycepin.

    [Key words] Cordycepin; Anti-inflammatory; Anti-tumor; Immune regulation; Hypoglycemic and lipid-lowering; Anti-aging; Application prospects ......