张珊珊 季一飞 蒲超

    [摘要] 目的 探討有氧运动联合叶酸治疗对阿尔茨海默病(AD)患者认知功能及血清细胞因子、血清同型半胱氨酸(Hcy)的影响。 方法 选择2016年5月～2018年1月四川省南充市中心医院诊治的86例AD患者作为研究对象，依据随机数字表法分为对照组和观察组，每组各43例。对照组给予盐酸多奈哌齐治疗+有氧运动训练，观察组在对照组基础上联合叶酸治疗，疗程为3个月。采用简明精神状态量表(MMSE)、阿尔茨海默病评价量表-认知分表(ADAS-cog)评定患者的认知功能，比较两组治疗前后血清Hcy、白细胞介素-6(IL-6)、IL-1β、肿瘤坏死因子-α(TNF-α)水平。 结果 治疗前两组MMSE评分、ADAS-cog评分比较，差异无统计学意义(P > 0.05)。治疗后，两组MMSE评分高于治疗前，且观察组高于对照组;两组ADAS-cog评分低于治疗前，且观察组低于对照组，差异均有统计学意义(均P 0.05)。治疗后，两组血清IL-6、TNF-α、IL-1β水平低于治疗前，且观察组低于对照组，差异均有统计学意义(均P 0.05). After treatment， MMSE scores in two groups were higher than those before treatment， and observation group were higher than control group. ADAS-cog scores of two groups were lower than those before treatment， and observation group was lower than control group， with statistically significant differences (all P 0.05). After treatment， serum levels of IL-6， TNF-α and IL-1β in two groups were lower than those before treatment ......