武明云 虞坚尔 白莉 薛征 蒋沈华 徐万超

    [摘要] 本文综述中药干预核转录因子-κB(NF-κB)信号通路中药治疗支气管哮喘的实验研究进展。NF-кB信号传导途径可以调控免疫/炎症细胞和气道结构细胞等，诱发支气管哮喘的发生及发展。近年来研究显示，多种中药复方、中药单味药及其提取物和中药单体可通过抑制NF-κB通路，减轻气道炎症和气道高反应，逆转气道重塑，在防治支气管哮喘方面有显著疗效。

    [关键词] 核转录因子信号通路;支气管哮喘;中药;综述

    [中图分类号] R562.25 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)04(a)-0031-04

    Progress of experimental research in the treatment of bronchial asthma with Chinese medicine based on NF-κB signaling pathway

    WU Mingyun1，2 ? YU Jian′er1 ? BAI Li3 ? XUE Zheng1，3 ? JIANG Shenhua1，2 ? XU Wanchao1，2

    1.Institute of Pediatrics of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai ? 200071， China; 2.Shanghai Clinical College of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai ? 201203， China; 3.Department of Pediatrics， Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine ......