韩广弢 李皓桓

    [摘要] 炎症可保护人体免受细胞变化引起的病原体和危险信号的损伤。尽管炎症是一种宿主防御机制，但是慢性炎症被认为是发展各种炎性自身免疫疾病的主要危险因素。风湿性疾病是全身性炎性和退化性疾病，其主要影响结缔组织，可导致严重的慢性结缔组织炎症，最终导致结缔组织的退变。人参及人参皂苷已被证明通过抑制炎症介质的表达和产生，对多种风湿性疾病具有抗炎活性和药理作用。本文对人参及人参皂苷进行简要概述，并讨论了最近研究其在风湿性疾病发病机制中的药理作用。这些见解可能会促进人参及人参皂苷类的药物发展，以预防和治疗风湿性疾病。

    [关键词] 人参;人参皂苷;炎症;巨噬细胞;风湿性疾病

    [中图分类号] R593.21 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)04(a)-0038-04

    Research progress of ginseng and ginsenoside in the treatment of rheumatic diseases

    HAN Guangtao ? LI Haohuan

    Department of Orthopedics， Renmin Hospital of Wuhan University， Hubei Province， Wuhan ? 430060， China

    [Abstract] Inflammation protects the body from pathogens and danger signals caused by cellular changes. Although inflammation is a host defense mechanism， chronic inflammation is considered a major risk factor for the development of various inflammatory autoimmune diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases， which mainly affect connective tissue and can lead to severe chronic connective tissue inflammation， ultimately leading to the degeneration of connective tissue. Ginseng and its ginsenoside have been proved to have anti-inflammatory activities and pharmacological effects on a variety of rheumatic diseases by inhibiting the expression and production of inflammatory mediators. This review gives a brief overview of ginseng and ginsenoside ......