张晓蕾 纪媛媛 王军 徐跃峤

    [摘要] 目的 分析开颅手术患者颅内感染的情况与相关危险因素。 方法 选取2018年1～12月首都医科大学宣武医院收治的开颅手术患者1088例，收集患者的一般资料及临床诊疗资料，使用logistic回归分析进一步分析。观察1088例开颅手术患者的颅内感染情况;分析影响开颅手术患者发生颅内感染的独立危险因素。 结果 1088例患者中，43例患者发生颅内感染。所有发生颅内感染的患者中，有4例(9.3%)发生死亡，其余39例在得到相应的治疗后顺利康复、出院。开颅手术患者发生颅内感染的独立危险因素为手术持续时间、引流管放置时间;手术持续时间[OR = 6.698，95%CI：3.511～12.780，P = 0.027]，引流管放置时间[OR = 2.603，95%CI：1.284～5.278，P = 0.018]。 结论 开颅手术患者发生颅内感染的风险概率较低，但死亡率高，影响开颅手术患者发生颅内感染的独立危险因素为手术持续时间、引流管放置时间。

    [关键词] 开颅手术;危险因素;颅内感染;引流管;手术时间

    [中图分类号] R619.3 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)04(b)-0124-04

    Investigation and risk factors analysis of intracranial infection in patients undergoing craniotomy

    ZHANG Xiaolei ? JI Yuanyuan ? WANG Jun ? XU Yueqiao

    Department of Neurosurgery， Xuanwu Hospital， Capital Medical University， Beijing ? 100053， China

    [Abstract] Objective To analyze the intracranial infection and related risk factors in patients undergoing craniotomy. Methods A total of 1088 patients with craniotomy who admitted to Xuanwu Hospital of Capital Medical University from January to December 2018 were selected. The general and clinical data of all patients were collected. Logistic regression analysis was used for further analysis. The intracranial infection in 1088 patients with craniotomy was observed and the ndependent risk factors for intracranial infection in patients undergoing craniotomy were analyzed. Results Among the 1088 patients ......