张亚楠 温海霞

    [摘要] 碳量子点是一类新型的荧光纳米材料，具备优异的导电性、极好的生物相容性能、环境友好性、稳定性能等优势，其在生物、医学、光学、纳米电子学、传感器等领域、肿瘤诊断中的靶向成像及肿瘤治疗中的药物靶向运输领域中取得巨大的进步。本文主要综述碳量子点的制备、生物特性、生物应用、在体内和体外成像以及生物体新的荧光标志物、药物传递、靶向治疗、缓解药物、延长药物作用时间提高药效以及在乳腺癌治疗中的未来应用前景。

    [关键词] 碳量子点;荧光探针;生物成像;乳腺癌

    [中图分类号] R73-3? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)05(a)-0069-04

    Application of carbon quantum dots in tumor therapy

    ZHANG Ya′nan? ?WEN Haixia▲

    Department of Physiology， Basic Medicine， Harbin Medical University， Heilongjiang Province， Harbin? ?150081， China

    [Abstract] Carbon quantum dots is a kind of new fluorescent nano material， has excellent electrical conductivity， excellent biological compatibility， environment friendly and stable performance advantages， it has made tremendous progress in the fields of biology， medicine， optics， nanoelectronics， sensors， etc.， tumor targeting imaging in the diagnosis and treatment of drug targeting. This paper mainly reviews the preparation， biological characteristics， biological applications of carbon quantum dots， in vivo and in vitro imaging， new fluorescence markers of organisms ......