胡兆勇 刘艳丽 谢赛飞 郑玲 谭劲

    [摘要] 组织纤维化是实质细胞发生坏死减少、纤维结缔组织增多的病理过程，可导致组织器官结构破坏、功能丧失，进而威胁人类健康和生命。外泌体是几乎所有细胞都能分泌的微小囊泡，携带了细胞内mRNA、蛋白质等多种物质，介导细胞间通讯并参与多种生物过程。近年来，关于外泌体和纤维化关系的研究越来越多。本文主要从外泌体调控纤维化、作为诊断纤维化的生物学标志物及治疗靶点方面进行综述。

    [关键词] 组织纤维化;外泌体;调控;生物学标志物;治疗靶点

    [中图分类号] R963? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)05(c)-0034-04

    Research progress on the relationship between exosomes and tissue fibrosis

    HU Zhaoyong1? ?LIU Yanli2? ?XIE Saifei3? ?ZHENG Ling3? ?TAN Jin3▲

    1.Anatomy Experiment Center， Medicine School， Hu′nan University of Chinese Medicine， Hu′nan Province， Changsha? ?410208， China; 2.Department of Diagnostics， Medicine School， Hu′nan University of Chinese Medicine， Hu′nan Province， Changsha? ?410208， China; 3.Department of Stomatology， the First Hospital of Hu′nan University of Chinese Medicine， Hu′nan Province， Changsha? ?410007， China

    [Abstract] Tissue fibrosis is a pathological process in which the necrosis of parenchymal cells is reduced and the fibrous connective tissue is increased， which can lead to the destruction of tissue and organ structure and loss of function ......