王雪 蒙臣 曾文 王轶铭 王贤裕 李清

    [摘要] 紧密连接分布于机体的各个组织器官和肿瘤组织，对屏障组织损伤修复和肿瘤组织发生发展均起着重要作用。表皮生长因子受体(EGFR)也广泛表达于这些组织中，其活化影响着屏障和肿瘤组织中紧密连接的状态变化，但影响却明显不同：激活EGFR信号通路能增强屏障组织中的紧密连接，抑制其破坏;但却使肿瘤细胞间的紧密连接减少，促使细胞离散转移。研究这种具体的影响和机制能为通过干预EGFR信号通路来治疗屏障功能损伤的相关疾病和肿瘤提供新的思路。

    [关键词] 表皮生长因子受体;紧密连接;组织损伤;修复;肿瘤侵袭

    [中图分类号] Q28? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)05(c)-0037-04

    Research progress on the effects and mechanisms of epithelial growth factor receptor on tight junction

    WANG Xue1，2? ?MENG Chen1，2? ?ZENG Wen1，2? ?WANG Yiming1，2? ?WANG Xianyu1，2? ?LI Qing1，2

    1.Department of Anesthesiology， Affiliated Hospital of Hubei University of Medicine (Taihe Hospital of Shiyan City)， Hubei Province， Shiyan? ?442000， China; 2.Institute of Anesthesiology， Department of Science and Technology， Hubei University of Medicine， Hubei Province， Shiyan? ?442000， China

    [Abstract] Tight junction is widely distributed in various organs and tumor tissues of the body， and plays an important role in the injury and repair of the barrier tissues， as well as in the development of the tumor tissues. Epithelial growth factor receptor (EGFR) is also expressed in these tissues ......