尚静 怀德 殷敏 张希龙 程雷 徐敏 解成兰

    [摘要] 目的 探讨阻塞性睡眠呼吸暫停低通气综合征(OSAHS)患者血浆白细胞介素-10(IL-10)、血管内皮生长因子(VEGF)水平变化及临床意义。 方法 选取2016年3月～2019年3月徐州医科大学附属淮安医院(以下简称“我院”)收治的OSAHS患者219例，所有OSAHS患者均行多导睡眠诊断分析系统(PSG)监测，根据每小时睡眠呼吸暂停次数(AHI)将其分为轻度OSAHS组(AHI：5～15次/h，n = 69)、中度OSAHS组(AHI：16～30次/h，n = 73)、重度OSAHS组(AHI：>30次/h，n = 77)。同期随机选取在我院行健康体检的志愿者60名为对照组。比较各组研究对象PSG监测指标;比较各组研究对象血浆IL-10、VEGF水平;采用多元逐步回归分析VEGF、IL-10与一般资料、PSG监测指标的相关性。 结果 OSAHS轻、中、重三组的AHI、氧饱和指数(ODI)、血氧饱和度(SaO2)≤90%占比均高于对照组，且呈依次升高趋势(P 30 times/h， n = 77). During the same period， 60 volunteers who underwent physical examination in our hospital were randomly selected as the control group. PSG monitoring indexes of each group were compared， plasma IL-10 and VEGF levels in each group were compared， the correlation of VEGF and IL-10 with general data and PSG monitoring indicators were analyzed by multiple stepwise regression. Results The proportion of AHI ......