宋莉平 王宇

    [摘要] 姜黄素是从中药姜黄中提取的一种植物多酚，也是姜黄发挥药理作用最重要的活性成分。现代药理学研究显示，姜黄素有抗肿瘤、抗炎、抗氧化、抗纤维化及心肌保护等药理作用。本文综合近些年文献，阐述姜黄素的抗肿瘤机制(包括抑制肿瘤细胞血管生成、抑制肿瘤细胞增殖、阻遏细胞周期、诱导细胞凋亡、抑制肿瘤细胞迁移和侵袭等)及姜黄素发挥抗炎、抗氧化、抗纤维化、心肌保护等作用治疗多种肿瘤、非肿瘤疾病，以期为姜黄素开发利用研究提供参考。

    [关键词] 姜黄素;药理作用;机制;肿瘤

    [中图分类号] R285.5 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)07(b)-0029-05

    [Abstract] Curcumin is a plant polyphenol extracted from turmeric of traditional Chinese medicine， and it is also the most important active component of turmeric to play a pharmacological role. Modern pharmacological studies have shown that curcumin has anti-tumor， anti-inflammatory， anti-oxidation， anti-fibrosis and myocardial protection and other pharmacological effects. This paper synthesizes the literature of recent years to elaborate the anti-tumor mechanism of curcumin (including inhibiting tumor cell angiogenesis， inhibiting tumor cell proliferation， repressing cell cycle， inducing apoptosis， inhibiting tumor cell migration and invasion， etc.) and the treatment of various tumor， non-tumor diseases by curcumin by exerting its anti-inflammatory ......