刘政 霍金海 侯金才 王伟明

    [摘要] 时至今日肺炎仍是影响全球的公共问题，依然是引起人类死亡的主要疾病。中医长期的临床实践总结而来的“肺与大肠相表里”理论依然具有指导作用。当前的生理与病理学的研究认为肺与大肠通过共同黏膜免疫系统相互影响。本文主要探究肺炎状况下机体产生免疫应答，引起黏膜免疫与肠道菌群相互作用;通过对肠道菌群与机体免疫系统相互影响进行综述，丰富肺炎发病机制的新思考、提供相关药物开发的新思路、充实“肺与大肠相表里”理论的新研究。

    [关键词] 肺炎;肠道菌群;黏膜免疫;肺与大肠相表里

    [中图分类号] R378 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)08(c)-0032-04

    Exploration of the relationship between intestinal flora and mucosal immunity and its research progress under pneumonia based on “lung and large intestine”

    LIU Zheng1 ? HUO Jinhai1，2 ? HOU Jincai2 ? WANG Weiming1

    1.Institute of Chinese Materia Medica， Heilongjiang Academy of Chinese Medical Sciences， Heilongjiang Province， Harbin ? 150036， China; 2.Shenwei Pharmaceutical Group Co.， Ltd， Hebei Province， Shijiazhuang ? 051430， China

    [Abstract] Today， pneumonia is a global public problem and the major cause of death. The theory of “lung and large intestine inside and outside” summarizes from the long-term clinical practice of traditional Chinese medicine still plays a guiding role. Current physiological and pathological studies suggest that the lung and the large intestine interact through mutual mucosal immunity. This paper mainly explores the immune response of the body under the condition of pneumonia ......