赵若涵 王立新 田风胜 白海龙

    [摘要] 血管病变为糖尿病的慢性并发症之一，基本涉及到心脏、肾、外周血管、眼等器官。随着病情的发展，氧化应激反应加剧，促使蛋白质酪氨酸残基硝基化形成3-硝基酪氨酸，同样，3-硝基酪氨酸的增加也加剧了糖尿病血管病变的发生发展，并引起越来越多人的重视。近年来，国内外关于3-硝基酪氨酸的研究越来越多，本文就近年来3-硝基酪氨酸和糖尿病血管病变关系的研究作一综述，为有效防止糖尿病血管病变提供可能。

    [关键词] 3-硝基酪氨酸;糖尿病;血管病变;研究进展

    [中图分类号] R58? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)09(a)-0045-04

    [Abstract] Vascular disease is one of the chronic complications of diabetes， basically involves the heart， the kidney， the peripheral blood vessel， the eye and so on. As the disease progresses， oxidative stress reaction aggravates， and promote the conversion of protein tyrosine residues to 3-nitrotyrosine. The increase of 3-nitrotyrosine exacerbates occurrence and development of diabetic vascular disease as well， and attracted more and more people′s attention. For the past few years， there are more and more studies on 3-nitrotyrosine in Chinese and Westerm medicine. This article reviews the recent advances in the study of relationship between 3-nitrotyrosine and diabetic vascular disease. It provides a possibility for the effective prevention and treatment of diabetic vascular disease. ......