刘冬 孔令提 徐海燕

    [摘要] 由于万古霉素耐药和不良反应等原因，利奈唑胺在治疗耐甲氧西林金黄色葡萄球菌等多重耐药及泛耐药细菌所致感染中的地位越来越高，然而，利奈唑胺应如何实现个体化用药尚无定论。研究显示利奈唑胺药动学特性受年龄、性别、体重、肝肾功能和基因等多种因素影响，导致疗效和不良反应的个体差异。目前已有多项研究肯定了治疗药物监测在个体化给药中的作用，但其应用价值尚有待于进一步证实。药动学/药效学研究显示应根据疾病状态和药物敏感试验结果等制订个体化给药方案。因此，临床药师应借助治疗药物监测和药动学/藥效学等工具积极参与临床治疗，从而提高利奈唑胺抗感染治疗的有效性和安全性。

    [关键词] 利奈唑胺;药动学;药效学;治疗药物监测;个体化给药

    [中图分类号] R969.3 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)09(b)-0034-04

    [Abstract] Due to Vancomycin resistance and adverse reactions， Linezolid has become increasingly important in the treatment of infections caused by Methicillin-Resistant Staphylococcus Aureus and other multi-resistant and pan-resistant bacteria. However， research on how Linezolid can be personalized medicine is still insufficient. Studies have shown that the pharmacokinetics of Linezolid are affected by various factors such as age， gender， weight， liver and kidney function， and genes， which can lead to individual differences in efficacy and adverse reactions. Many studies have confirmed the role of therapeutic drug monitoring in the individualized administration of linezolid ......