魏华英 杨洋 曾静 仵永枫 画伟 郭彩萍 张玉林

    [摘要] 结核病(TB)是人类免疫缺陷病毒感染者中常见的主要机会性感染和死亡的主要原因之一。艾滋病(AIDS)合并结核病患者的治疗也因抗逆转录病毒治疗药物和抗结核药物可能有相似的代谢和消除途径而复杂化，因此合并感染者的治疗药物选择至关重要，本文将简述AIDS合并TB患者治疗方案进展及药物相互作用与药物肝毒性。

    [关键词] 艾滋病;结核病;肝毒性;药物相互作用

    [中图分类号] R512.91? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)09(c)-0037-03

    Advances in the treatment of AIDS complicated with tuberculosis

    WEI Huaying? ?YANG Yang? ?ZENG Jing? ?WU Yongfeng? ?HUA Wei? ?GUO Caiping? ?ZHANG Yulin▲

    Department of Infectious Center， Beijing Youan Hospital， Capital Medical University， Beijing? ?100069， China

    [Abstract] Tuberculosis (TB) is one of the leading opportunistic infections and causes of death among people infected with the human immunodeficiency virus. The treatment of AIDS patients with tuberculosis (AIDS) is complicated by the fact that antiretroviral (ART) drugs and anti-TB drugs may have similar metabolic and elimination pathways. Therefore， the choice of treatment drugs for coinfected persons is very important. This article will briefly describe the progress of treatment regimens， drug interactions and drug hepatotoxicity in AIDS patients with TB. ......