程筱涵 齐靖 白玉华 郑晓东

    [摘要] 肺动脉高压(PAH)是以肺动脉压力和肺血管阻力升高为特征的致死性心血管疾病。野百合碱(MCT)引起的PAH病理特征和临床患者十分相似。MCT可以通過炎症反应、内皮途径以及调节肺动脉平滑肌细胞的增殖等因素诱导PAH的发生。因此本文对近几年MCT诱导PAH动物模型的作用机制以及在PAH新治疗药物靶点筛选中的应用进行简要综述。

    [关键词] 肺动脉高压;野百合碱;信号通路;药物靶点

    [中图分类号] R322.1? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)09(c)-0040-04

    Advanced mechanisms and potential clinical application value of monocrotaline-induced pulmonary artery hypertension animal model

    CHENG Xiaohan1? ?QI Jing2? ?BAI Yuhua1? ?ZHENG Xiaodong2

    1.College of Pharmacy， Harbin Medical University(Daqing)， Heilongjiang Province， Daqing? ?163319， China; 2.College of Basic Medical Sciences， Harbin Medical University (Daqing)， Heilongjiang Province， Daqing? ?163319， China

    [Abstract] Pulmonary artery hypertension (PAH) is a fatal cardiovascular disease characterized by increases in pulmonary artery pressure and pulmonary vascular resistance. The pathological features of PAH induced by monocrotaline (MCT) are similar to those of clinical patients. MCT-induced PAH through multiple factors including inflammatory response ......