田莎莎 杨晓鹏 郭珲

    [摘要] 糖尿病肾病(DN)是糖尿病微血管病变的主要并发症之一，已成为我国导致慢性肾脏疾病的首要原因，深入了解DN的发病机制，寻找新的诊断及治疗靶点至关重要。微小RNA(miRNA)作为一种普遍存在的非编码小分子RNA，广泛参与基因转录后调节及表观遗传调节等过程，其表达或功能异常在DN的发生发展中起重要作用，介导了DN中肾组织纤维化、炎症反应、足细胞凋亡等病理生理改变。近年来miRNA对DN早期诊断及预后判断的价值得到证实，同时通过抑制或重建miRNA将其作为DN的治疗靶点也逐步应用于临床。但是miRNA在DN的发病机制及临床应用中仍存在极大地挑战。

    [关键词] 糖尿病肾病;微小RNA;生物标志物;治疗靶点

    [中图分类号] R587.2? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)09(c)-0058-04

    Advancements of microRNA in diabetic nephropathy

    TIAN Shasha1? ?YANG Xiaopeng1? ?GUO Hui1，2

    1.Department of Nephrology， the Second Hospital of Shanxi Medical University， Shanxi Province， Taiyuan? ?030000， China; 2.Department of Nephrology， Shenzhen Baoan Shiyan People′s Hospital， Guangdong Province， Shenzhen? ?518005， China

    [Abstract] Diabetic nephropathy (DN) is one of the main complications of diabetic microangiopathy and has been the leading cause of chronic kidney disease in China. It′s important to understand the pathogenesis and find new diagnostic and therapeutic targets of DN. MicroRNA (miRNA)， as a ubiquitous non-coding small molecular RNA， is widely involved in gene post-transcriptional and epigenetic regulations. The expression or abnormal function play an important role in the occurrence and development of DN ......