杨妮 徐建良 盛国光

    [摘要] 代谢组学可通过对机体内小分子代谢物进行精准定性定量，分析代谢物与机体生理及病理相关变化的关系，揭示疾病本质及寻找疾病标志物。目前尚未发现治疗肝纤维化特异有效的西药，临床上使用中药及中成药治疗肝纤维化效果显著。近年来代谢组学技术发展迅速，为中药治疗肝纤维化领域的研究提供了新的技术平台。本文主要对近5年代谢组学在中医药治疗肝纤维化领域的研究进展进行综述。

    [关键词] 肝纤维化;代谢组学;中药;生物标志物;研究进展

    [中图分类号] R575? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)10(b)-0033-04

    [Abstract] Metabolomics can reveal the nature of disease and look for disease markers through accurate qualitative and quantitative analysis of small molecular metabolites in the body， and analyze the relationship between metabolites and physiological and pathological changes. At present， no specific and effective Western medicine has been found in the treatment of liver fibrosis. The clinical use of traditional Chinese medicine and Chinese patent medicine has a significant effect on liver fibrosis. In recent years， metabolomics technology has developed rapidly， which provides a new technology platform for the research of traditional Chinese medicine treatment of liver fibrosis. This article mainly reviews the research progress of metabolomics in the treatment of liver fibrosis with traditional Chinese medicine in recent five years. ......