钟森杰 李静 李琳

    [摘要] 慢性心衰的病理过程中伴随着一系列代谢功能的复杂改变，代谢组学通过先进的检测技术与统计算法，可以从整体层面把握机体的代谢功能改变情况，现已成为心衰实验研究的常用手段。本文归纳总结代谢组学技术在慢性心衰病证诊断中的研究概况，基于“代谢性重构”理论阐述慢性心衰的代谢特征，探讨慢性心衰不同证候的代谢组学变化规律，认为代谢组学技术对心衰的病情评价及证型辨析具有一定的诊断价值。并对研究中存在的关键问题进行论述，提出规范统一研究标准、合理设计对照实验、注重心衰病证的动态过程研究等相应的思路，以期为后续研究提供借鉴。

    [关键词] 慢性心衰;代谢组学;生物标志物;诊断研究

    [中图分类号] R259? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)10(b)-0040-05

    [Abstract] The pathological process of chronic heart failure is accompanied by a series of complex changes of metabolic function. Metabolomics can grasp the metabolic function changes of the body from the overall level through advanced detection technology and statistical algorithms， which has now become a common means of experimental research on heart failure. This article summarizes metabonomics technology in the diagnosis of chronic heart failure disease research， based on the theory of “metabolic remodeling”， the metabolic characteristics of chronic heart failure are expounded， and the metabonomics change rules of different syndromes of chronic heart failure are discussed. It is believed that metabonomics technology has certain diagnostic value for the assessment of heart failure and the discrimination of syndrome types of heart failure. In addition ......