莫辉 徐岷

    [摘要] 微小RNA(microRNAs)是一类短的非编码RNA，大量研究表明其与恶性肿瘤的发生发展密切相关。microRNA-1290作为microRNAs家族的一员，近年来越来越多的研究发现其在多种消化系统肿瘤(包括食管癌、胃癌、胰腺癌、结直肠癌、肝脏肿瘤等)中表达异常，且可能与肿瘤的增殖、侵袭、迁移、凋亡及不良预后等密切相关，本文就microRNA-1290在多种消化系统肿瘤中研究进展作一综述，以期为基于microRNA-1290的抗肿瘤治疗研究提供新的思路。

    [关键词] 肿瘤;消化系统;微小RNA;microRNA-1290;研究进展

    [中图分类号] R57? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)10(b)-0048-04

    [Abstract] MicroRNAs (microRNAs， miRNAs) are a type of short non-coding RNA. A large number of studies have shown that they are closely related to the occurrence and development of malignant tumors. As a member of the microRNAs family， microRNA-1290 has been increasingly researched in recent years and found in various digestive system tumors (including esophageal cancer， gastric cancer， pancreatic cancer， colorectal cancer， liver tumor， etc.) The expression is abnormal， and may be closely related to tumor proliferation， invasion， migration， apoptosis and poor prognosis. This article reviews the research progress of microRNA-1290 in various digestive system tumors， hoping to provide new ideas for anti-tumor therupy research based on microRNA-1290. ......