门冬氨酸钾镁的保肝和退黄疸作用(1)
【摘要】 目的 观察门冬氨酸钾镁对D-氨基半乳糖和异硫氰酸-1-萘酯(ANIT)引起的大鼠肝损伤的保护作用。方法 大鼠预先给予门冬氨酸钾镁5 d后，注射D-氨基半乳糖和异硫氰酸-1-萘酯，观察肝脏受损后血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、胆红素的水平，并进行病理切片检查。结果 门冬氨酸钾镁2、4 ml/kg可以显著降低由D-氨基半乳糖引起的AST以及ANIT引起的血清总胆红素升高。结论 门冬氨酸钾镁可以拮抗D-氨基半乳糖和ANIT引起的肝损伤，有一定的保肝作用。【关键词】门冬氨酸钾镁；肝损伤；D-氨基半乳糖；异硫氰酸萘酯
The hepatic protection and biliary lowering effects of potassium magnesium aspartate
ZHANG Yun-yi,LI Pei-fen.Department of Pharmacology,School of Pharmacy,Fudan University ,Shanghai 200032,China
【Abstract】 Objective To study the protective effect on the hepatic damage induced by D-Galactosamine and 1-naphthyl isothiocyanate.Methods Rats were orally given potassium magnesium aspartate for 5 days.Then rats were treated with D-Galactosamine or 1-naphthyl isothiocyanate.The serum AST,ALT and bilirubin were tested.Results 2 and 4 ml/kg potassium magnesium aspartate decreased the high AST level which induced by D-galactosamine and serum total biliary induced by 1-naphthyl isothiocyanate.Conclusion Potassium magnesium aspartate had the protective effects against the hepatic damage caused by D-galactosamine and 1-naphthyl isothiocyanate. ......
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