坦索罗辛和山莨菪碱在输尿管下段结石辅助排石中作用的应用(1)
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【摘要】 目的 分析坦索罗辛和654-2在输尿管下段结石辅助排石中疗效。方法 120例输尿管下段结石患者随机分3组，每组40例。结石直径0.4~0.8 cm。组1为对照组，未给予输尿管平滑肌松弛剂；组2给予654-2 10 mg,3次/d；组3给予坦索罗辛0.4 mg,1次/d。每例患者治疗观察期不超过2周。结果 2周内结石排出者组1为17例(42.5%)，组2为29例(72.5%)，组3为33例(82.5%)，组2、3与组1比较排石率差异有统计学意义(P<0.05)。平均排石时间组1~3分别为10、7、4 d，组1与组3比较差异有统计学意义(P<0.05)，组2与组3比较差异无统计学意义(P>0.05)。2周内组1~3因再次发生肾绞痛而需镇痛治疗者分别为12例(30%)、5例(12.5%)和1例(2.5%)，组间比较差异有统计学意义(P<0.05)。2周内3组均未出现明显不良反应，无因不能耐受而退出者。 结论 坦索罗辛和654-2在输尿管下段结石辅助排石方面安全、有效，能明显提高排石率。
【Key words】 输尿管结石；坦索罗辛；山莨菪碱
Comparison of tamsulosin versus 654-2 for the management of lower ureteral stones
XIN Yi-jun.Department of urology,Penglai Hospital,China
【Abstract】 Objective To compare the efficacy of tamsulosin and anisodimine for the adjunctive expulsive therapy in patients with lower ureteral stones.Methods A total of 120 patients with stones(0.4-0.8 cm in diameter)located in the lower ureter(juxtavesical or intramural tract)were randomly divided into 3 groups(40 cases in each group).Group 1 served as controls; group 2 received anisodimine(10 mg,3 times daily); and group 3 received tamsulosin(0.4 mg,once daily).All patients were observed for 2 weeks.Results During 2 weeks,expulsion of stones was observed in 17 cases(42.5%)of group 1,in 29(72.5%)of group 2,and 33(82.5%)of group 3.The difference in expulsion rates between groups 2,3 and group 1 was statistically significant(P<0.05).The mean expulsion time of groups 1,2 and 3 was 10,7 and 4 d,respectively,with significant difference between groups 1 and 3(P<0.05),but no significant difference between group 2 and 3(P>0.05).In groups 1,2 and 3,renal colic recurred within 2 weeks and analgesics were used in 12 cases(30%),5(12.5%)and 1(2.5%),respectively,with significant difference between the groups(P<0.05).All the patients tolerated the expulsive therapy and no one withdrew from treatment.No obvious side effect occurred.Conclusions It is demonstrated that tamsulosin and anisodimine are safe and effective for adjunctive expulsive treatment for lower ureteral stones.They both can significantly improve the stone expulsion rate.
【Key words】Ureteral calculi;Tamsulosin;anisodimine
2005年1月至2007年8月笔者对门诊120例输尿管下段结石患者进行分组研究 ......
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