论文下载：内分泌腺来源的血管内皮生长因子在多囊卵巢中的表达及意义

内分泌腺来源的血管内皮生长因子在多囊卵巢中的表达及意义(1)

http://www.100md.com 2011年2月15日吴丽姝任凤岩王春晓卜素芝王丹波

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     【摘要】目的研究内分泌腺来源的血管内皮生长因子(EGVEGF)在多囊卵巢的表达，并与血管内皮生长因子(VEGF)的表达进行比较，探讨EGVEGF在多囊卵巢综合征(PCOS)发病机制中的作用。方法采用免疫组化SP法检测多囊卵巢及正常卵巢组织中EGVEGF及VEGF的表达情况。结果 EGVEGF在研究组中的表达水平显著高于对照组(P=0.001)。VEGF在研究组中的表达水平明显高于对照组(P=0.021)。研究组中EGVEGF的表达水平高于VEGF的表达水平(P=0.036)，二者表达无相关性(P=0.327)。对照组中EGVEGF的表达水平略高于VEGF的表达水平，但差异无统计学意义(P=0.655)，二者表达仍无相关性(P=0.928)。结论 EGVEGF蛋白的过度表达促进多囊卵巢综合征患者的血管生成，与多囊卵巢综合征的发生相关。

    【关键词】

    多囊卵巢综合征；内分泌腺来源的血管内皮生长因子；血管内皮生长因子；免疫组化

    The expression and significance of endocrine glandderived vascular endothelial growth factor in polycystic oraries

    WU Lishu,REN Fengyan,WANG Chunxiao,et al.

    Department of Obstetrics and Gynecology,The People’s Hospital of Daqing HeiLongJiang，163316,China

    

    【Abstract】 Objective To research the expression of EGVEGF in polycystic ovaries and compare with VEGF,in order to explore the role of EGVEGF in development and progression of PCOS. Methods The expression of EGVEGF and VEGF in polycystic ovaries and normal ovarian tissues were detected by immunohistochemistry.Results The expression levels of EGVEGF in the study group were significantly higher than those in the control group(P=0.001). The expression levels of VEGF in the study group were significantly higher than those in the control group(P=0.021). The expression levels of EGVEGF in the study group were higher than that of VEGF(P=0.036),but there was no dependablity between the two factors(P=0.327). The expression levels of EGVEGF in the control group were a little higher than that of VEGF,but there were no statistically significant(P=0.655),and there was no dependablity between the two factors(P=0.928). Conclusion Overexpression of EGVEGFpromote angiogenesis of polycystic ovary syndrome and is associated with the progression of polycystic ovary syndrome. 

    【Key words】

    Polycystic ovary syndrome; EGVEGF；VEGF；Immunohistochemistry

    多囊卵巢综合征(PCOS)是常见的育龄妇女内分泌疾病之一，以卵泡内膜及间质的增生和过度血管化为主要特征,发病率为6%~8%。多年来由于确切的发病机制不清，一直缺乏理想的治疗手段。目前研究表明，血管生成及其相关因子在PCOS的发病中有一定的作用[1，2]。内分泌腺来源的血管内皮生长因子(Endocrine Glandderived Vascular Endothelial Growth Factor，EGVEGF)是最近发现的一个组织特异性血管内皮生长因子，主要表达在生成类固醇的内分泌腺组织，如卵巢、睾丸、肾上腺和胎盘组织[36]，可能与血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)互补 ......

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