米非司酮配伍米索前列醇用于负压吸引流产术前的效果观察
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【摘要】 目的 观察米非司酮配伍米索前列醇用于负压吸引流产术的效果。方法 对100例妊娠7~10周要求终止妊娠的妇女予米非司酮75 mg口服，每日早上空腹口服,连续2 d，第3天负压吸引流产术前肛门置入米索前列醇400 μg(观察组)，另选择100例情况相同的妇女在术中宫颈注射利多卡因5 ml(对照组)。观察两组妇女手术中宫颈松弛程度、疼痛程度、人工流产综合征(RAAS)发生率、宫颈宫腔粘连发生率、出血量及药物不良反应。结果 两组妇女宫颈松弛效果比较，差异有统计学意义(P<0.01)；两组妇女术中疼痛程度比较，差异有统计学意义(P<0.01)；两组妇女人工流产综合征(RAAS)发生率、宫颈宫腔粘连发生率比较，差异有统计学意义(P<0.05)；两组妇女术中出血量比较，差异无统计学意义(P>0.05)；两组孕妇均有少数出现药物不良反应，症状轻微，短时间内消失。结论 米非司酮配伍米索前列醇用于负压吸引流产术前, 方法简便、安全、有效，值得在临床上推广。
【关键词】 负压吸引流产术；妊娠妇女；米非司酮；米索前列醇
Effect of Mifepristone compatible with Misoprostol for vacuum aspiration
GAN Chang-xun, CAI Peng-yu, WEI Li,et al.
The People’s Hospital of Dongguan City,Dongguan 523000,China
【Abstract】 Objective To observe the effect of Mifepristone compatible with misoprostol for vacuum asporation. Methods Observe groop: 100 women who pragnacy with 7 to 10 weeks and desire to end the pragnacy were given Mifepristone 75 mg by mouth on an empty stomach every morning for two days and were given misoprostol 400 μg by anus on the third day before vacuum asporation. Control groop: 100 women with the same conditions were injected Lidocaine 5 ml by cervix on operation. The degree of cervix chalasia, degree of pain, incidence of artificial abortion syndrome, incidence of accrecio of uterus and cervix, hemorrhage amount and side reaction of drugs were observed . Results There was a significant difference in the the degree of cervix chalasia, degree of pain, incidence of artificial abortion syndrome, incidence of accrecio of uterus and cervix between observe groop and control groop(P<0.01). There was no significant difference in hemorrhage amount between two groops(P>0.05).A few women in two groops had light side reaction of drugs and disappeared soon. Conclusion The method of Mifepristone compatible with Misoprostol for vacuum asporation is convenient, safety and effective which deserves generalization in clinical.
【Key words】 Vacuum aspiration; Pragnacy woman; Mifepristone; Misoprostol
人工流产是世界上许多国家控制生育最常用的方法之一[1]。人工流产分为手术流产和药物流产两种方法。药物流产限制在妊娠7周内，而7周以上早孕妇女只能采用负压吸引流产术。为减轻负压吸引流产术中的疼痛，我们采用在术前给受术者使用米非司酮和米索前列醇的方法并做临床观察，现将结果报告如下。
1 资料与方法
1.1 一般资料 选择2007年1月至2008年12月在我院门诊自愿选择负压吸引流产术妇女200例 ......
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