不同胰岛素注射方式治疗初发2型糖尿病疗效观察
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【摘要】 目的 探讨短期胰岛素泵强化治疗(CSII)和传统胰岛素两次皮下注射(TDI)对初发2型糖尿病患者治疗效果。方法 将63例初发2型糖尿病患者随机分成CSII组和TDⅠ组，以末梢血空腹﹤7.0 mmol/L,餐后2 h﹤10.0 mmol/L为控制目标。观察血糖达标时间、每日胰岛素用量、低血糖发生次数及治疗前后血糖、C肽、糖化血红蛋白、血脂、体质指数变化。结果 CSⅡ组血糖达标的时间短、胰岛素用量少(P<0.05)，低血糖发生次数无统计学差异。治疗前后对比，CSⅡ组血糖明显下降，胆固醇、甘油三酯略有下降，体质指数不增加。CSⅡ组，C-肽明显增加，TDⅠ组增加不明显。结论 CSII治疗效果明显优于TDI。
【关键词】 初发2型糖尿病；CSIITDI
Curative Effect Observation of Differ Insulin Infection on Newly Diagnosed Type II Diabetic Patients WANG Xiu-hua, YANG Xue-lian, JIANG Lv-zhi
【Abstract】 Objective Investigate the short-term effects of continuous subcutaneous insulin injection(CSII) and traditional two daily infection(TDI) in the treatment of newly diagnosed type 2 diabetic patients. Methods 63 newly diagnosed type 2 diabetic patients were randomly divided into CSII groupand TDI group. The target of glycemia control were fasting blood glucose <7.0 mmol/L and postprandial blood glucose <10.0 mmol/L. The time needed for blood glucose to normal. the amount of insulin used,the number of hypoglycemia,and blood glucose, C-Peptide, HbA1 c, blood fat, BMI before and after therapy were observed.Results Compared with TDI group. The time needed for blood glucose to normal was shorter. the amount of insulin used was less.the number of hypoglycemia happened was not different.Compared with before therapy. Blood glucose was significantly lower. TC and TG were slightly lower, BMI was not increase after therapy. In CSII group. C-peptide increased evidently. But no significant change in TDI group. Conclusion The treatment of control blood glucose with CSII was more efficient.
【Key words】 Newly diagnosed type II diabetes; CSIITDI
1 临床资料与方法
1.1 一般资料 根据WHO1999年的诊断标准，初诊的2型糖尿病63人，随机分成两组，一组给予CSII强化控制血糖，共32人，其中，男14人，女18人。另一组给予诺和灵30R用诺和笔一天两次皮下注射。共31人，男12人，女19人。两组在年龄、性别及体质指数方面无统计学差异。
1.2 试验方法
1.2.1 检测指标 每天检测指尖血糖8次，治疗前后均行馒头餐试验检测0 h、30 min、60 min、2 h的C肽及静脉血糖。
1.2.2 方法 CSⅡ组采用美国MiniMed507 c型胰岛素泵输入诺和灵R，三餐前加用大剂量。将胰岛素总量50%作为基础量 ......
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