舒心丸对急性心肌梗死再灌注后心肌微循环的影响(1)
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【摘要】 目的 探讨舒心丸对急性心肌梗死(AMI)溶栓再灌注后，患者体内血浆内皮素(ET-1)、超敏C反应蛋白(hs-CRP)、血栓素A2(TXA2)、一氧化氮(NO)水平、5-HT的变化及其临床意义。方法 86例急性心肌梗死溶栓再灌注患者，均接受西医常规治疗，随机分为2组：治疗组43例，治疗组在西医常规治疗上加用舒心丸，1包/次，3次/d，疗程为15 d，对照组43例，分别测出治疗前后ET-1、NO、Hs-CRP、TXA2、5-HT水平的变化。结果 治疗前后ET、hs-CRP、TXA2和NO 水平治疗组治疗15 d后ON水平显著高于对照组(P<0.01)，较对照组也明显提高(P<0.05),对照组治疗前后则无明显变化(P>0.05)；血清ET-1、hs-CRP、TXA2水平较前明显降低(P<0.01),与对照组明显降低(P<0.01)，而对照组治疗后各项指标较前下降，但差异无统计学意义(P>0.05)。结论 舒心丸能防治急性心肌梗死溶栓再灌注后心肌微循环障碍，而且安全、价廉，未见明显的毒副作用。其可能机制是通过调节血浆ET-1、NO、Hs-CRP、TXA2水平,促进心肌微循环恢复。
【关键词】 舒心丸；急性心肌梗死；再灌注；心肌微循环
Shuxin pill on myocardial microcirculation after acute myocardial infarction and reperfusion in rats
HE Qing-jun,ZHANG Hua-yun,LUO Zi-xing,et al.
Hospital of Traditional Chinese Medicine of Fuoshan City,Guagndong 528000,China
【Abstract】 Objective
Study on Shuxin pill on acute myocardial infarction (AMI) after Thrombolysis-reperfusion, plasma endothelin of patients (ET-1), high-sensitivity c-reactive protein (hs-CRP), thromboxane A2(TXA2), nitric oxide (NO) levels, changes of 5-HT and its clinical significance. Methods 86 cases of acute myocardial infarction patients with thrombolysis-reperfusion, western medicine in treatment were accepted, randomly divided into 2 groups: group of 43 cases treated, the treatment group on western medicine treatment plus with shuxin pill, 1 bag at a time, three times a day, 15-day course, control groups in 43 cases, respectively measured before and after treatment with ET-1, NO, Hs-CRP, changes in levels of TXA2, 5-HT. Results Before and after treatment with ET, hs-CRP, levels of TXA2 and NO treatment group therapy ON levels significantly higher than the control group after 15 days (P<0.01), than the control group also significantly improve (P<0.05), controlled before and after treatment with no obvious change (P>0.05).Serum levels of ET-1, hs-CRP, TXA2 more significantly reduced (P<0.01), with a control group significantly reduced (P<0.01), the indexes fell earlier after the treatment and control groups, but not statistically significant (P>0 ......
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