难治性癫痫患者致痫灶中CX43的表达(2)
本实验通过免疫组织化学及免疫电镜方法对癫痫患者脑组织中CX43的表达进行观察，结果显示实验组及对照组脑组织中均检测到CX43的阳性细胞，实验组脑组织CX43阳性细胞数为(505±97)，而对照组CX43阳性细胞数为(120±70)，差异有统计学意义。CX43在难治性癫痫致痫灶脑组织中的表达增加，提示缝隙连接参与了癫痫的发生及发展，在脑皮质发育、神经网络及环路的重组、神经细胞间离子通道的构成等方面发挥着重要作用。
参 考 文 献
[1] 徐姜定难治性癫痫治疗进展. 浙江临床医, 2006,8(10):10091010.
[2] 姚伯昕缝隙连接与癫痫. 海南医学, 2009, 20(6): 132135.
[3] Nakagawa S, Maeda S, Tsukihara T Structural and functional studies of gap junction channels. Curr Opin Struct Biol, 2010, 20(4): 423430.
[4] Goodenough DA, Paul DL Gap junctions.Cold Spring Harb Perspect Biol, 2009, 1(1):2576.
[5] Meldrum BS, Rogawski MA Molecular targets for antiepileptic drug development. Neurotherapeutics, 2007 4(1): 1861.
[6] Verma V, Larsen BD, Coombs W, et al Novel Pharmacophores of Connexin43 Based on the “RXP” Series of Cx43Binding Peptides. Circ Res, 2009, 105: 176184.
[7] Goodenough DA, Paul DL Gap junctions. Cold Spring Harb Perspect Biol, 2009, 1(1):2576.
[8] OrthmannMurphy JL, Abrams CK, Scherer SS Gap junctions couple astrocytes and oligodendrocytes. J Mol Neurosci, 2008, 35(1): 101116.
[9] Meldrum BS, Rogawski MA Molecular targets for antiepileptic drug development. Neurotherapeutics, 2007, 4(1):1861.
[10] Chew SS, Johnson CS, Green CR, et al Role of connexin43 in central nervous system injury. Exp Neurol, 2010, 225(2): 250261., 百拇医药(张立志 冯俊强 陈晶 宋宏杉 陈业鹏)
参 考 文 献
[1] 徐姜定难治性癫痫治疗进展. 浙江临床医, 2006,8(10):10091010.
[2] 姚伯昕缝隙连接与癫痫. 海南医学, 2009, 20(6): 132135.
[3] Nakagawa S, Maeda S, Tsukihara T Structural and functional studies of gap junction channels. Curr Opin Struct Biol, 2010, 20(4): 423430.
[4] Goodenough DA, Paul DL Gap junctions.Cold Spring Harb Perspect Biol, 2009, 1(1):2576.
[5] Meldrum BS, Rogawski MA Molecular targets for antiepileptic drug development. Neurotherapeutics, 2007 4(1): 1861.
[6] Verma V, Larsen BD, Coombs W, et al Novel Pharmacophores of Connexin43 Based on the “RXP” Series of Cx43Binding Peptides. Circ Res, 2009, 105: 176184.
[7] Goodenough DA, Paul DL Gap junctions. Cold Spring Harb Perspect Biol, 2009, 1(1):2576.
[8] OrthmannMurphy JL, Abrams CK, Scherer SS Gap junctions couple astrocytes and oligodendrocytes. J Mol Neurosci, 2008, 35(1): 101116.
[9] Meldrum BS, Rogawski MA Molecular targets for antiepileptic drug development. Neurotherapeutics, 2007, 4(1):1861.
[10] Chew SS, Johnson CS, Green CR, et al Role of connexin43 in central nervous system injury. Exp Neurol, 2010, 225(2): 250261., 百拇医药(张立志 冯俊强 陈晶 宋宏杉 陈业鹏)