益生菌联合阿奇霉素治疗小儿急性肠胃炎临床疗效分析(1)
【摘要】 目的 分析益生菌聯合阿奇霉素治疗小儿急性肠胃炎的临床疗效。方法 140例小儿急性肠胃炎患儿， 采用双盲随机法分为观察组与对照组， 各70例。对照组采用阿奇霉素治疗， 观察组在对照组基础上联合益生菌治疗。观察并比较两组症状(腹痛、腹泻、发热、呕吐)缓解时间、临床疗效、住院时间以及不良反应(嗜睡、高热、皮疹)发生情况。结果 观察组患儿腹痛、腹泻、发热、呕吐缓解时间分别为(3.2±1.1)、(4.1±1.3)、(2.1±1.2)、(3.1±1.2)d， 均短于对照组的(7.5±2.3)、(8.2±3.1)、(7.2±2.4)、(8.2±3.2)d， 差异具有统计学意义(P<0.05)。观察组患儿治疗总有效率为98.57%， 高于对照组的80.00%， 差异具有统计学意义(P<0.05)。观察组患儿住院时间为(5.2±1.2)d， 短于对照组的(9.5±2.4)d， 差异具有统计学意义(P<0.05)。观察组患儿不良反应发生率为4.29%(3/70)， 低于对照组的25.71%(18/70)， 差异具有统计学意义(P<0.05)。结论 针对小儿急性肠胃炎采用益生菌联合阿奇霉素治疗的疗效显著， 可快速缓解患儿各种临床症状， 不良反应较少， 可促进患儿病情康复， 且安全性较高， 值得临床应用推广。
【关键词】 小儿急性肠胃炎;益生菌;阿奇霉素;联合治疗;临床疗效
DOI：10.14163/j.cnki.11-5547/r.2019.21.046
【Abstract】 Objective To analyze the clinical efficacy of probiotics combined with azithromycin in the treatment of pediatric acute gastroenteritis. Methods A total of 140 acute gastroenteritis children were divided by random double-blind method into observation group and control group， with 70 cases in each group. The control group was treated with azithromycin and the observation group was treated with probiotics on the basis of the control group. Observation and comparison were made on symptoms (abdominal pain， diarrhea， fever， vomiting) remission time， clinical efficacy， hospitalization time and occurrence of adverse reactions (drowsiness， fever， rash) between the two groups. Results The observation group had shorter remission time of abdominal pain， diarrhea， fever and vomiting respectively as (3.2±1.1)， (4.1±1.3)， (2.1±1.2) and (3.1±1.2) d than (7.5±2.3)， (8.2±3.1)， (7.2±2.4) and (8.2±3.2) d in the control group， and their difference was statistically significant (P<0.05). The observation group had higher total treatment effective rate as 98.57% than 80.00% in the control group， and the difference was statistically significant (P<0.05). The observation group had shorter hospitalization time as (5.2±1.2) d than (9.5±2.4) d in the control group， and the difference was statistically significant (P<0.05). The observation group had lower incidence of adverse reactions as 4.29%(3/70) than 25.71%(18/70) in the control group， and the difference was statistically significant (P<0.05). Conclusion Probiotics combined with azithromycin shows remarkable effect for children with acute gastroenteritis， and it can quickly alleviate various clinical symptoms of children with fewer adverse reactions， promote the rehabilitation of children with high safety. It is worthy of clinical application and promotion., 百拇医药(刘楠)
【关键词】 小儿急性肠胃炎;益生菌;阿奇霉素;联合治疗;临床疗效
DOI：10.14163/j.cnki.11-5547/r.2019.21.046
【Abstract】 Objective To analyze the clinical efficacy of probiotics combined with azithromycin in the treatment of pediatric acute gastroenteritis. Methods A total of 140 acute gastroenteritis children were divided by random double-blind method into observation group and control group， with 70 cases in each group. The control group was treated with azithromycin and the observation group was treated with probiotics on the basis of the control group. Observation and comparison were made on symptoms (abdominal pain， diarrhea， fever， vomiting) remission time， clinical efficacy， hospitalization time and occurrence of adverse reactions (drowsiness， fever， rash) between the two groups. Results The observation group had shorter remission time of abdominal pain， diarrhea， fever and vomiting respectively as (3.2±1.1)， (4.1±1.3)， (2.1±1.2) and (3.1±1.2) d than (7.5±2.3)， (8.2±3.1)， (7.2±2.4) and (8.2±3.2) d in the control group， and their difference was statistically significant (P<0.05). The observation group had higher total treatment effective rate as 98.57% than 80.00% in the control group， and the difference was statistically significant (P<0.05). The observation group had shorter hospitalization time as (5.2±1.2) d than (9.5±2.4) d in the control group， and the difference was statistically significant (P<0.05). The observation group had lower incidence of adverse reactions as 4.29%(3/70) than 25.71%(18/70) in the control group， and the difference was statistically significant (P<0.05). Conclusion Probiotics combined with azithromycin shows remarkable effect for children with acute gastroenteritis， and it can quickly alleviate various clinical symptoms of children with fewer adverse reactions， promote the rehabilitation of children with high safety. It is worthy of clinical application and promotion., 百拇医药(刘楠)