降脂消斑通脉膏治疗下肢动脉硬化闭塞症Ⅱ期的疗效研究(1)
【摘要】 目的 觀察降脂消斑通脉膏治疗下肢动脉硬化闭塞症(ASO)Ⅱ期患者的临床疗效。方法 80例ASO Ⅱ期患者， 随机分成A组和B组， 每组40例。A组予降脂消斑通脉膏治疗， B组予前列地尔注射液治疗。比较两组患者的临床疗效， 治疗前后踝肱指数(ABI)， 血脂指标， 血流变学指标， 双侧胫前、足背动脉内径， 股浅动脉内膜中层厚度(IMT)、斑块厚度(PT)、斑块面积(PA)。结果 A组总有效率90.00%明显高于B组的67.50%， 差异有统计学意义(P<0.05)。治疗后， 两组ABI均高于治疗前， 且A组ABI(0.89±0.29)高于B组的(0.75±0.27)， 差异有统计学意义(P<0.05)。A组治疗后总胆固醇(CHOL)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平均优于治疗前， 差异有统计学意义(P<0.05)。A组治疗后高切、中切、低切全血粘度及血浆粘度均优于治疗前， 差异有统计学意义(P<0.05)。A组和B组治疗前左胫前动脉 、右胫前动脉及左足背动脉 、右足背动脉与本组治疗后比较， 差异有统计学意义(P<0.05)。A组治疗前IMT、PT、PA与治疗后比较， 差异有统计学意义(P<0.05)。结论 降脂消斑通脉膏治疗ASO疗效较好， 优于单纯前列地尔治疗， 其具有显著的调血脂、降低血粘度、缓解痉挛、扩张血管、消除斑块等综合治疗作用， 具有推广和进一步研究价值。
【关键词】 下肢动脉硬化闭塞症;中医药疗法;降脂消斑通脉膏;前列地尔注射液
DOI：10.14163/j.cnki.11-5547/r.2020.31.004
Effect of Jiangzhi Xiaoban Tongmai Ointment in the treatment of lower limb stage Ⅱ arteriosclerosis obliterans WU Jian-hua， ZHANG Han-chao， JU Zhen-guo， et al. Xuzhou Hospital of Traditional Chinese Medicine， Xuzhou 221003， China
【Abstract】 Objective To observe the clinical efficacy of Jiangzhi Xiaoban Tongmai Ointment in the treatment of lower limb arteriosclerosis obliterans (ASO) stage Ⅱ. Methods A total of 80 patients with stage Ⅱ ASO were randomly divided into group A and group B， with 40 cases in each group. Group A was treated with Jiangzhi Xiaoban Tongmai Ointment， and group B was treated with alprostadil injection. The clinical efficacy， ankle brachial index (ABI)， blood lipid index， blood rheology index， bilateral anterior tibial and dorsal foot artery diameter， intima-media thickness (IMT)， plaque thickness (PT)， plaque area (PA) before and after treatment were compared between the two groups. Results The total effective rate 90.00% of group A was obviously higher than 67.50% of group B， and the difference was statistically significant (P<0.05). After treatment， ABI of the two groups were higher than those before treatment， and ABI (0.89±0.29) of group A was higher than (0.75±0.27) of group B， and the difference was statistically significant (P<0.05). After treatment， total cholesterol (CHOL)， triglycerides (TG)， low density lipoprotein cholesterol (LDL-C)， high density lipoprotein cholesterol (HDL-C) of group A were better than those before treatment， and the difference was statistically significant (P<0.05). After treatment， high-cut， mid-cut， low-cut whole blood viscosity and plasma viscosity of group A were better than those before treatment， and the difference was statistically significant (P<0.05). The left anterior tibial artery， right anterior tibial artery， left dorsal pedis artery and right dorsal pedis artery of group A and group B after treatment had statistically significant difference compared with those before treatment (P<0.05). In group A， there was statistically significant difference in IMT， PT and PA before and after treatment (P<0.05). Conclusion Jiangzhi Xiaoban Tongmai Ointment is effective in the treatment of ASO and is superior to alprostadil. It has combined therapeutic effect， such as regulating blood fat， reducing blood viscosity， relieving spasm， dilating blood vessels and eliminating plaque， etc. It has the value of popularization and further research., http://www.100md.com(吴建华 张汉超 鞠振国 王轶 王海青)
【关键词】 下肢动脉硬化闭塞症;中医药疗法;降脂消斑通脉膏;前列地尔注射液
DOI：10.14163/j.cnki.11-5547/r.2020.31.004
Effect of Jiangzhi Xiaoban Tongmai Ointment in the treatment of lower limb stage Ⅱ arteriosclerosis obliterans WU Jian-hua， ZHANG Han-chao， JU Zhen-guo， et al. Xuzhou Hospital of Traditional Chinese Medicine， Xuzhou 221003， China
【Abstract】 Objective To observe the clinical efficacy of Jiangzhi Xiaoban Tongmai Ointment in the treatment of lower limb arteriosclerosis obliterans (ASO) stage Ⅱ. Methods A total of 80 patients with stage Ⅱ ASO were randomly divided into group A and group B， with 40 cases in each group. Group A was treated with Jiangzhi Xiaoban Tongmai Ointment， and group B was treated with alprostadil injection. The clinical efficacy， ankle brachial index (ABI)， blood lipid index， blood rheology index， bilateral anterior tibial and dorsal foot artery diameter， intima-media thickness (IMT)， plaque thickness (PT)， plaque area (PA) before and after treatment were compared between the two groups. Results The total effective rate 90.00% of group A was obviously higher than 67.50% of group B， and the difference was statistically significant (P<0.05). After treatment， ABI of the two groups were higher than those before treatment， and ABI (0.89±0.29) of group A was higher than (0.75±0.27) of group B， and the difference was statistically significant (P<0.05). After treatment， total cholesterol (CHOL)， triglycerides (TG)， low density lipoprotein cholesterol (LDL-C)， high density lipoprotein cholesterol (HDL-C) of group A were better than those before treatment， and the difference was statistically significant (P<0.05). After treatment， high-cut， mid-cut， low-cut whole blood viscosity and plasma viscosity of group A were better than those before treatment， and the difference was statistically significant (P<0.05). The left anterior tibial artery， right anterior tibial artery， left dorsal pedis artery and right dorsal pedis artery of group A and group B after treatment had statistically significant difference compared with those before treatment (P<0.05). In group A， there was statistically significant difference in IMT， PT and PA before and after treatment (P<0.05). Conclusion Jiangzhi Xiaoban Tongmai Ointment is effective in the treatment of ASO and is superior to alprostadil. It has combined therapeutic effect， such as regulating blood fat， reducing blood viscosity， relieving spasm， dilating blood vessels and eliminating plaque， etc. It has the value of popularization and further research., http://www.100md.com(吴建华 张汉超 鞠振国 王轶 王海青)