D240检测LVD与胃癌临床病理的关系(1)
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【摘要】 目的 探讨胃癌组织淋巴管密度(lymphotic vessel density,LVD)与临床病理的关系。方法 免疫组织化学检测胃癌组织D240的表达,并计数LVD。结果 52例胃癌总LVD均值为18.19.7,肿瘤内及边缘分别为16.449.62、19.9010.13,明显高于正常胃组织6.583.87(P<0.05)。低分化胃癌边缘23.211.6显著高于高中分化胃癌15.75.9(P<0.05)。淋巴结转移者21.910.8较无淋巴结转移者14.95.9显著升高(P<0.05)。胃癌边缘LVD与浸润深度、临床分期及肿瘤内与边缘无显著性差异。结论 胃癌肿瘤内与边缘LVD显著高于正常组织,与分化程度及淋巴结转移相关,提示LVD增加可能与胃癌的侵袭转移有关。
【关键词】
胃癌;D240;淋巴管密度;转移
Correlations of lymphatic vessel density and clinicopathologic parameters in gastric carcinoma detected by D240
WU Yongjun,LI Zheng,ZHANG Yang,et al.Cancer Research Institute,University of South China,Hengyang 421001,China
【Abstract】 Objective To investigate the correlations oflymphatic vessel density(LVD)and clinicopathologic parameters in gastric carcinoma.Methods Theexpression of monoclonal antibody D240 was detected by immunohistochemistry and to count LVD in gastric carcinoma.Results LVD mean was 18.19.7 in 52 cases of gastric carcinoma.19.9010.13 and 16.449.62 in the peritumoural and intratumoural area,respectively,were significantly higher than 6.583.87 in normal gastric tissue(P<0.05).23.211.6 of poorlydifferentiated was significantly higher than 15.75.9 of differentiated in peritumoural area(P<0.05).21.910.8 in lymphatic metastasis was obviously higher than 14.95.9 in nonmetastasis(P<0.05).LVD of edges in gastric carcinoma was not related with invasion depth and clinical stage(P>0.05)。There no was significant difference between LVD in peritumoral and intratumoural areas(P>0.05).Conclusion LVD in the peritumoural and intratumoural area were significantly higher than in normal gastric tissue,and closely associated with differentiation degree and mestasis.It is suggest that LVD increasing may be concerned with metastasis in gastric carcinoma.
【Key words】
Stomach neoplasm;D240;Lymphatic vessel density;Metastasis
胃癌是世界上肿瘤相关死因第二位的恶性肿瘤。我国
DOI:10.3760/cma.j.issn 16738799.2010.01.03
基金项目:湖南省科技厅科技计划(项目编号:2008SK3010);湘潭市科技局科技计划项目(项目编号:SF20081003);湖南省重点学科建设项目基金(项目编号:2006180)
作者单位:421001衡阳,南华大学肿瘤研究所(吴勇军 苏琦);
湘潭市第一人民医院/南华大学湘潭临床学院(吴勇军 李筝 张漾 赵毅 伍镇江)
胃癌发病率占世界的42%,并且,死亡率占全部恶性肿瘤死亡的23.2%,为欧美发达国家的4.2~8.0倍[1,2]。由于患者就诊时大多已经发生侵袭转移,手术、化疗、放疗等疗效均差。因此,寻找侵袭转移的标记物、制定更加完善的治疗方案已成为目前研究的热点 ......
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