CerbB2在乳腺癌中的表达与转移的相关性分析(1)
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【摘要】 目的 分析乳腺癌CerbB2的表达与年龄、肿瘤大小、病理学类型、腋窝淋巴结转移及远处转移的相关性。方法 应用免疫组化SP法对69例原发性乳腺癌行根治及改良根治术的标本进行了CerbB2的检测,并进行统计学分析。结果 CerbB2阳性表达率为73.9%(51/69);CerbB2的阳性表达率与淋巴结转移及有远处转移有关(P<0.05),而与患者年龄、肿瘤大小、病理学类型无关(P>0.05)。结论 CerbB2的阳性表达与淋巴结转移程度呈正相关,与年龄、肿瘤大小、病理学类型及远处转移不相关。CerbB2的过表达与淋巴结转移及远处转移相关。CerbB2可作为判断乳腺癌预后的指标。
【关键词】
CerbB2;乳腺癌;转移
Relationship between the expression of CerbB2 in breast cancer and metastasis
PAN Haiyan,GUAN Xiaodong,JIA Yingbin.
The department of general Surgery,The Fifth Affiliated Hospital of Zhongshan University 519000,China Guangzhou
【Abstract】 Objective To investigate the relationship between the expression of CerbB2 in breast cancer and the age,tumor size,pathological type of cancer and lymphnode metastasis and other organ metastasis in breast cancer patients.Methods Immunohistochemical SP method was used for the detection of CerbB2 in specimens taken from 69 breast cancer patients undergoing radical treatment or modified radical treatment.χ2Statistical analysis was used.Results The positive expression rates of CerbB2 were 73.9%(51/69)(+34.8%,++10.1%,+++29.0%),and the positive expression rates of them were associated with lymph node metastasis(P<0.05),but not related to patient’s age,tumor size,histologicaltype and other organ metastasis(P>0.05).The overexpression of CerbB2 were associated with lymph node metastasis and other organ metastasis.Conclusion The positive expression rates of CerbB2 were related to lymph node metastasis,but not related to patient’s age,tumor size and histological type.They can be used to predict the prognosis of breast cancer patients.
【Key words】
CerbB2;Breastneoplasms;Metastasis
DOI:10.3760/cma.j.issn 16738799.2010.01.07
作者单位:519000中山大学附属第五医院普外三科
乳腺癌是女性常见的恶性肿瘤之一,全世界每年约有120万妇女发生乳腺癌,约50万妇女死于乳腺癌[1]。在我国占全身各种恶性肿瘤的7%~10%,并呈逐年上升趋势,且有发病年龄提早的趋向,部分大城市报告乳腺癌占女性恶性肿瘤之首位(外科学)。研究表明CerbB2在部分乳腺癌存在基因扩增和过表达,不仅与其发生发展有一定关系,而且是判断乳腺癌预后和化疗效果的重要生物标记之一[2,3]。因此,CerbB2的检测已成为一个研究热点,且具有指导临床治疗的重要意义。本研究用免疫组化SP法检测了69例乳腺癌病理蜡块中CerbB2的表达情况并分析了与其他病理因素及转移之间的关系。
1 材料与方法
1.1 材料 随机抽取中山大学附属第五医院2001年5月至2004年5月手术切除乳腺癌石蜡包埋标本69例 ......
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