亚低温对重症脑出血手术治疗患者血清神经元特异性烯醇化酶和血糖的影响(1)
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【摘要】 目的 研究亚低温对重症脑出血手术治疗患者血清神经元特异性烯醇化酶(NSE)和血糖的影响。方法 82例重症脑出血患者随机分为治疗组和对照组,对照组除了不进行亚低温治疗外其他治疗方法与治疗组相同,分别于治疗前和治疗第3、5、7 d测外周血NES和血糖,3个月时进行GOS预后评分。结果 治疗组治疗后外周血NSE和血糖与对照组比较差异有统计学意义,GOS预后评分明显优于对照组(P<0.05)。结论 亚低温能降低重症脑出血患者的血清NSE和血糖,对神经元细胞有良好的保护性作用。
【关键词】
亚低温;出血性脑血管病;神经元烯醇化酶;预后
Influence of mild hypothermia therapy on serum levels of blood neuronspecific enolase and glucose in the patients of severe cerebral hemorrhage
LI Lizhong,ZHAO Shizhu.Department of neurology,the Hospital,Hebi Coal industry general group,Hebi,458000,China
【Abstract】 Objective To study the influence of mild hypothermia therapy on serum levels of blood neuronspecific enolase(NSE)and glucose in the patients of severe cerebral hemorrhage.Methods 82 severecerebral hemorrhage patients were randomly assigned into the treatment group(n=41)and the control group(n=41).Besides the routine treatment,mild hypothermia was used in the treatment group and their temperatures were maintained between 32℃ and 34℃ for 7 days.The control group received only routine treatment.NSE and blood glucose were measured in the two groups before the treatment and at 3rd,5th,7th day after the treatment.Prognosis was evaluated with GOS at 3 months.Results NSE and blood glucose level in the treatment group were lower than those in the control group after the treatment,there was significant difference between the two groups.GOS of treatment group was better than that of control group at 3 months(P<0.05).Conclusion Mild hypothermia is one of effective method for the treatment of the patients with severe cerebral hemorrhage.It can reduce the NSE and blood glucose levels of patients and protect neurons.
【Key words】
Mild hypothermia;Cerebral hemorrhage;Neuronspecific enolase(NSE);Prognosis
DOI:10.3760/cma.j.issn 16738799.2010.01.57
作者单位:458000河南省鹤壁市鹤壁煤业集团总医院外科
近年来,高血压脑出血患者的手术治疗的疗效得到肯定,但对亚低温的治疗仍有争议[1,2]。笔者根据血清神经元特异性烯醇化酶(neuronspecific enolase,NSE)和血糖的动态变化,从临床角度进一步观察亚低温对重症脑出血患者的治疗效果,现报告如下。
1 资料与方法
1.1 一般资料 入选病例为本院ICU 2006年1月至2008年6月收住的发病24 h内就诊的初发急性高血压脑出血患者82例为观察对象,男50例,女32例,年龄39~78岁,平均(53 ......
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