资料下载：丹参对重症急性胰腺炎血管活性物质及肝功能干预作用的研究

丹参对重症急性胰腺炎血管活性物质及肝功能干预作用的研究(1)

http://www.100md.com 2010年2月1日王媛媛康利民王伟

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     【摘要】目的通过观察丹参对重症急性胰腺炎血浆TXA2、PGI1浓度及肝功能的变化,探讨丹参对改善重症急性胰腺炎患者肝损害的作用。方法 57例重症急性胰腺炎肝损害患者在入院随机分为2组,即对照组28例和丹参组29例,分别行常规治疗和丹参治疗14 d。检测其TXA2、PGI1及肝功能的改变。结果入院时两组TXA2,TXA2/PGI1比值无明显差别,入院后3,7,14 d丹参组较对照组显著降低(P<0.05或P<0.01),而PGI1各时间点两组无显著差异(P>0.05);丹参组14 d后肝功能各项指标均恢复正常,与对照组比较有统计学意义(P<0.05或P<0.01)。结论丹参对于SAP肝损害的治疗有显著的临床疗效,丹参可能通过纠正血管收缩/舒张因子之间的平衡而改善肝脏微循环,这可能是其治疗SAP肝损害的作用机理之一。

    【关键词】重症急性胰腺炎;肝损害;丹参;血栓素A2/前列环素

    The effect of Salvia miltiorrhiza on vasoactive substance and hepatic function in severe acute pancreatitis

    WANG Yuan yuan,KANG Li min,WANG Wei.Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China

    【Abstract】 Objective To explore the changes of TXA2,PGI1 and hepatic function as well as effects of salvia miltiorrhiza on the patiente with server acute pancreatitis hepatic injury.Methods 57 patitnts with SAP were randomly divided ito control group and salvia miltiorrhiza treatment group.Patientes in control group received routine treatment,and the patients in salvia miltiorrhiza treatment group received additional salvia miltiorrhiza.The changes of plasma TXA2,PGI1 and hepatic function were conitored and compared between them.Results Plasma TXA2,the ratio of TXA2/PGI1 were significantly lower in the salvia miltiorrhiza group as compared with the control group on the 3,7,14 d after treatment(P<0.05 or P<0.01);but there were no obvious difference in the plasma PGI1 levels at each time point.The hepatic function in the salvia miltiorrhiza group were change normal after 14 days,which had signification difference than those in the control gruop P<0.05orP<0.01).Conclusion The salvia miltiorrhiza had a significant efficacy to treated the SAPhepatic injure.salvia miltiorrhiza may correct the imbalance between constrictionand factor and relaxation factor to improve the microcirculation of hepatic,and this was one of the mechanisms of salvia miltiorrhiza in treatment of SAP hepatic injure.

    【Key words】 Server acute pancreatitis; Hepatic injure; Salvia miltiorrhiza;TXA2/PGI1

    DOI:10.3760/cma.j.issn 1673 8799.2010.02.03

    作者单位:116001辽宁省大连大学附属中山医院

    重症急性胰腺炎(server acute pancreatitis,SAP)是临床常见的急腹症,死亡率高达20%~40% ......

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