心力衰竭患者血清瘦素\胰岛素抵抗与心功能的关系(1)
 |
| 第1页 |
参见附件(1389KB，2页)。
【摘要】 目的 探讨心力衰竭(简称心衰)患者血清瘦素水平、胰岛素抵抗(IR)与心衰严重程度的关系。方法 选择心衰患者90例,按NYHA心功能分级分为三组(心功能Ⅱ级、心功能Ⅲ级、心功能Ⅳ级组),每组30例。健康对照组60例,放免法测定血清瘦素、空腹胰岛素(FINS)水平,全自动生化分析仪测定空腹血糖(FBG)水平,并计算胰岛素抵抗指数(HOMA IR)。结果 心衰组血清瘦素、胰岛素抵抗水平较对照组显著增高(P<0.01);心衰组瘦素,胰岛素抵抗水平按NYHA分级分别为:NYHA分级Ⅱ级为(8.17±4.39)ng/L、1.98±0.96,NYHA分级Ⅲ级为(11.28±4.95)ng/L、3.48±1.26,NYHA分级Ⅳ级为(14.29±5.85)ng/L、5.32±1.52,差异有统计学意义(P<0.05)。结论 心衰患者血清瘦素、胰岛素抵抗水平显著升高,并与心衰严重程度存在一定相关性,可以较准确地评价患者心衰的严重程度。
【关键词】心力衰竭;瘦素; 胰岛素抵抗
Study on the relationship between serum leptin and insulin resistance and cardiac function
PAN Shi jun,YANG Zhong xi,XUE Xiu yan.HanTing People’s Hospital,Weifang 261100,China
【Abstract】 Objective To explore the relations between serum leptin and insulin resistance(IR)and the degree of heart failure.Methods 150subjects were selected,including 60 healthy controls and 90 patients with heart failure.We determined the concentration of fasting insulin(FINS)and leptin in serum in these patients by radioimmunoassay.Insulin resistance index was calculated to evaluate insulin resistance degree.Results The concentrations of leptin and HOMA IR in heart failure cases were significant higher than those in the control group(P<0.01)and it was also showed that the more severe the heart failure,the higher the leptin and HOMA IR[(8.17±4.39)ng/L,(1.98±0.96)in class Ⅱ,(11.28±4.95)ng/L,(3.48±1.26)in class Ⅲ,(14.29±5.85)ng/L,(5.32±1.52)in class Ⅳ,(P<0.05)].Conclusion The serum leptin concentrations and degree of insulin resistance were significantly higher in patients with heart failure,they are correlative with the degree of heart failure,and may evaluate the severe degree of heart failure.
【Key words】 Heart failure; Leptin; Insulin resistance
心力衰竭(简称心衰)是各种心血管疾病最主要的死亡原因,其发病率呈逐年上升的趋势,因此探讨心衰的发生发展机制,为其防治提供理论依据一直是研究重点。瘦素(leptim)作为肥胖基因的表达产物,由脂肪细胞分泌,是一种重要的机体能量平衡的调节因子,参与机体能量代谢。研究已显示,瘦素不仅与肥胖、糖尿病等关系密切,且认为是缺血性心脏病的独立危险因素[1]。而新近发现在慢性心衰患者有明显胰岛素抵抗及瘦素水平显著升高。目前瘦素,胰岛素抵抗在慢性心衰的作用还很不清楚。本研究目的在于探讨慢性心力衰竭患者血清瘦素及胰岛素抵抗水平与心功能不全严重程度的关系,初步探讨其在心衰病理过程中意义。
1 资料与方法
1.1 一般资料 心衰组:2008年12月至2009年6月在我院诊断为心衰的住院患者90例,年龄42~78岁(平均63.87岁);其中冠心病42例,高血压性心脏病18例,扩张型心脏病10例,风湿性心脏病20例 ......
您现在查看是摘要介绍页，详见PDF附件(1389KB，2页)。