寻常型银屑病患者血清金属蛋白酶 2和抵抗素含量变化的意义(1)
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【摘要】 目的 检测寻常型银屑病患者血清中金属蛋白酶 2(MMP 2)和抵抗素含量变化,探讨其在治疗前后的关系。方法 采用双抗体夹心酶联免疫技术(ELISA)检测70例寻常型银屑病患者治疗前、中及治疗后血清中MMP 2和抵抗素含量、另检测30例正常人血清中的MMP 2和抵抗素含量作为对照组。结果 寻常型银屑病患者血清中MMP 2和抵抗素含量较对照组显著增高(t=9.42,8.76,P值均<0.01),进行期与静止期MMP 2和抵抗素含量差异有统计学意义(t=3.45,4.38,P值均<0.05)。治疗前后患者血清中MMP 2和抵抗素含量差异也有统计学意义(t=6.47,8.53,P值均<0.05),且两者之间存在正相关(r=0.68,P<0.05)。结论 MMP 2和抵抗素可能参与银屑病的发病并起着一定作用。
【关键词】银屑病; 金属蛋白酶; 抵抗素
The Observation of Dynamic Stateon the Level of the Peripheral Blood MMP 2 and Resistin in Patients with Psoriasis Vulgaris
LAN Cui xia,HUANG You min.Clinical Laboratory,Qingdao Haici Hospital,Qingdao 266033,China
【Abstract】 Objective The changes of serum MMP 2 and resistin levels in psoriasis vulgaris were measured,and study the relationship between those cytokins.Methods Levels of MMP 2 and resistin in serum were measured by double antibody sandwichenzy melinked immunosorbent assay(ELISA)in 70 patients with psoriasis vulgaris before and after treatment and normal controls.Results Serum levels of MMP 2 and resistin were significant increased in patients with psoriasis vulgaris as compared with normal controls(t=9.42,8.76,all P<0.01),and there was statistical significant(t=3.45,4.38,all P<0.05).Serum levels of MMP 2 and resistin were significant in 70 patients with psoriasis vulgaris before and after treatment(t=6.47,8.53,all P<0.05).There was positive correlation between the concentrations of resistin and MMP 2(r=0.68,P<0.05).Conclusion The MMP 2 and resistin may be very important to the pathogenesis of psoriasis vulgaris.
【Key words】 Psoriasis; MMP; Resistin
银屑病发病机理不详,目前普遍认为它是一种发生在遗传基础上的炎症性、增生性皮肤病。金属蛋白酶(MMPs)是一组依赖锌离子的内肽酶,是细胞外基质和基底膜降解主要酶类之一。研究表明金属蛋白酶(MMPs)是银屑病的新生血管形成的重要因素,在银屑病的发病中起重要作用[1]。抵抗素(resistin)是并与炎症反应密切相关的细胞因子[2]。为探讨基质金属蛋白酶 2(MMP 2)和抵抗素在寻常型银屑病发病中的作用及临床意义,特对两者的含量进行了检测。
DOI:10.3760/cma.j.issn 1673 8799.2010.02.13
作者单位: 266033青岛市海慈集团检验科(兰翠霞); 滕州市中心人民医院输血科(黄友敏)
1 资料与方法
1.1 一般资料 2008年4月至2009年10月在本院门诊就治的寻常型银屑病患者共70例,根据《临床皮肤病学》[3]的诊断标准确诊,所有患者均经病理活检证实诊断。男42例,女28例,年龄(38.31±3.34)岁。进行期38例,静止期32例,病程从2年到10余年不等。所有银屑病患者近2个月内未系统服用维A酸、类固醇激素=免疫抑制剂等药物。2周内未使用任何外用药物。另取30例正常人血清作为对照组,其中男18例,女12例,年龄(37.63±3.29)岁;均为来本院健康查体人员,无免疫性疾病及系统性疾病,无银屑病家族史。对照组与银屑病患者组在性别及年龄上差异无统计学意义 ......
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