甲亢患者外周血白细胞及其VCS参数观察(1)
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【摘要】目的分析甲状腺功能亢进症(甲亢)患者外周血白细胞数量及其VCS变化。 方法以LH750全自动血细胞分析仪对60例甲亢患者外周血白细胞检测,比较白细胞及其分类的数量变化;同时进行VCS参数的数据分析。结果60例甲亢患者单核细胞相对计数和单核细胞绝对计数分别为(9.0±3.1)%、(4.8±1.9)×108/L,均高于对照组的(6.5±2.3)%、(3.6±1.2)×108/L,两组之间差别显著(P<0.01)。甲亢患者具有LMR、中性粒细胞V均值、淋巴细胞C均值均降低的特征。LMR的敏感性和特异性分别为72.7%、50.8%(cutoff值=4.0)。中性粒细胞V均值、淋巴细胞C均值对甲亢的诊断具有较高的敏感度(ROC下面积分别为0.629、0.706)。结论甲亢患者外周血单核细胞数量上升,LMR比值降低,白细胞VCS参数有助于临床上甲亢的诊断。
【关键词】
甲亢;白细胞;分类;VCS
Changes of leukocyte and its VCS parameters in peripheral blood of hyperthyroidism patients
REN Xiaoying,JIN Xuhong,ZHENG Yanqing,et al.Department of Clinic Laboratory,Xiamen First Hospital,Xiamen 361005,China
【Abstract】ObjectiveTo analyze the changes of leukocyte and its VCS parameters in peripheral blood of hyperthyroidism patients.MethodsLeukocyte in peripheral blood of 60 hyperthyroidism patients were detected by using Beckman Coulter LH750 hematology analyzer,meanwhile classification and VCS parameters of leukocyte were analyzed.ResultsThe relative and absolute counting of monocytes in 60 hyperthyroidism patients were(9.0±3.1)%、(4.8±1.9)×108/L respectively,which were significantly higher than those of healthy controls(P<0.01).LMR,neutrophil V means and lymphocyte C means were decreased in hyperthyroidism patients.The sensitivity and specificity of LMR were 72.7%,50.8%(cutoff=4.0)respectively.Neutrophil V means and lymphocyte C means showed a high sensitivity for the diagnosis of hyperthyroidism(areas under the ROC curves were 0.629、0.706 respectively).ConclusionAn increased monocytes and a decreased LMR ration were found in hyperthyroidism patients,which made leukocyte and its VCS parameters contribute to diagnose of hyperthyroidism.
【Key words】
Hyperthyroidism; Leukocyte; Classification; VCS
甲状腺功能亢进症(Hyperthroidism,简称甲亢)为常见病、多发病,是由多种原因导致甲状腺功能增强、甲状腺激素分泌过多或因甲状腺激素在血液中水平增高所导致的机体
DOI:10.3760/cma.j.issn 16738799.2010.03.06
作者单位:361003福建省厦门市第一医院检验科
多系统的一系列高代谢症候群,主要临床表现为:多食、消瘦、畏热、多汗、心悸、激动等[1]。目前认为本病系自身免疫性疾病,患者血清中存在具有能与甲状腺组织起反应或刺激作用的自身抗体。淋巴细胞是机体免疫系统的主要细胞, 单核细胞和各种粒细胞参与免疫应答和免疫反应[2,3] ......
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