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急性心肌梗死患者血浆脂联素和超敏C反应蛋白的临床分析(2)

http://www.100md.com 2010年3月1日马香稳王宪李建

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     CRP是一种在肝细胞内合成的,在急性时相反应中变化最显著、最敏感、最重要的急性时相蛋白质,是反映机体炎性反应的客观指标,也是预测冠心病危险性的强有力指标,调节CRP含量可控制动脉粥样硬化的进展[12,13]。此外近年来多项大规模前瞻性研究证实hsCRP是健康人群将来发生心肌梗死和脑卒中强烈的独立预测因子[14]。本研究显示AMI患者中hsCRP浓度显著高于对照组。

    综上所述,血浆APN浓度在AMI患者中明显降低,而hsCRP水平明显升高,且二者与左心室射血分数(LVEF)呈负相关,这些研究提示APN和hsCRP测定将是AMI危险分层的必要手段之一,同时二者结合对于判断AMI预后也有很高的预测价值。

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