阿托伐他汀对老年脑梗死伴高血脂患者颈动脉粥样硬化斑块的影响(1)
 |
| 第1页 |
参见附件(2260KB，3页)。
【摘要】 目的 探讨阿托伐他汀的降脂疗效及对老年脑梗死伴高血脂患者颈动脉粥样硬化斑块的影响。方法 采取治疗前后自身对照比较的方法,选择50例脑梗死合并颈动脉粥样硬化斑块患者,给予阿托伐他汀10 mg,qn总疗程1年,分别测定治疗前及治疗后6~12个月的血脂、颈动脉内膜-中层厚度、颈动脉斑块面积的变化。结果 阿托伐他汀治疗6~12个月后,TC、LDL-C、TG降低(P<0.05),HDL-C升高(P<0.01);颈动脉的内径有所扩大,颈动脉斑块缩小,尤以12个月后改变显著(P<0.01)。结论 阿托伐他汀降脂疗效确切,减少并稳定斑块的作用。
【关键词】阿托伐他汀;脑梗死;高血脂;颈动脉粥样硬化斑块
Effect of atorvastatin on arteriosclerosis plaque of carotid arteryin elder patients with cerebral infarction and hypercholesterolemia
GENG Gui-ling,LI Zhong-mei,LI Yi-ju,et al.
Department of dispensary,Liaocheng second hospital,Affiliated hospital of Taishan Medical University Shandong province,Linqing 252600,China
【Abstract】 Objective To investigate the effect of atorvastatin on arteriosclerosis plaque of carotid arteryin elder patients with cerebral infarction and hypercholesterolemia. Methods With self-comparsion of before and after treatment,50 subjects with arteriosclerosis plaque of carotid artery were given atorvastatin 10 mg, qn for 12 months. After treatment 6and 12 months, arteriosclerosis plaque of carotid artery、 intima-media thickness and peak index were measured in all patients. Results After 6 and 12 months adminstration of atorvastatin, TC、TG、LDL-C were all reduced (P<0.05), and HDL-C was elevated (P<0.01) in all patients. The initial diameter of carotid was significantly enlarged in 12 months (P<0.01). The size of plaque decreased (P<0.01) in 12 months after atorvastatin therapy than before(P<0.01). Conclusion The effect of atorvastatin is certain and it can stabilize the plaque of carotid artery.
【Key words】 Atorvastatin;Cerebral infarction;Hypercholesterolumia;Arteriosclerosis plaque of carotid artery
多种大规模研究已证实,颈动脉粥样硬化与脑血管疾病有着密切的关系。动脉粥样硬化是一种慢性、进展性、系统性的炎性反应疾病。动脉粥样硬化斑块的破裂、出血导致的血栓形成是脑梗死的主要病理基础。颈动脉内膜-中层厚度(inti ma-media thickness, IMT)的变化可以评估血管硬化的程度,颈动脉斑块是在颈动脉硬化的基础上产生的。近期研究表明,阿托伐他汀作为新型组织选择性甲基戊二酸单酰辅酶A(HMG-CoA)还原酶抑制剂,在降低总胆固醇和低密度脂蛋白(LDL)胆固醇的同时,还可以改善内皮功能、降低血小板聚集性和血栓沉积,并减轻血管炎症反应。本研究旨在探讨应用新型调脂药阿托伐他汀对老年脑梗死患者颈动脉粥样硬化斑块的影响。
1 资料与方法
1.1 一般资料 选择本院门诊及住院的老年脑梗死伴高血脂患者50例。其中男31例,女19例;平均年龄(67.2±8.6)岁。血浆胆固醇(TC)浓度>5.70 mmol/L,三酰甘油(TG)>1.71 mmo1/L。50例患者均符合1995年全国第四届脑血管病会议制定的《各类脑血管病诊断要点》[1] ......
您现在查看是摘要介绍页，详见PDF附件(2260KB，3页)。