血尿酸与冠心病的相关性及对血小板聚集功能的影响(1)

http://www.100md.com 2010年5月1日 钟伟文 洪树辉

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     【摘要】 目的 探讨血尿酸与冠心病的相关性及尿酸水平的变化对血小板聚集功能的影响。方法 将120例疑诊为冠心病的患者根据冠状动脉造影结果分为冠心病组(85例)和正常对照组(35例),比较两组间尿酸水平及血小板最大聚集率(MPAR)的差异。同时对冠心病伴高尿酸血症患者进行别嘌醇干预治疗4周,对比分析用药前后尿酸水平及血小板最大聚集率的变化。结果 冠心病组血尿酸、MPAR水平显著高于对照组(P<0.05),单因素相关分析发现冠心病组血尿酸水平与血小板聚集率呈正相关关系(r=0.598,P<0.05),冠心病伴高尿酸血症患者服药后血尿酸、MPAR水平显著低于服药前(P<0.05),差别均有统计学意义。结论 尿酸可激活血小板,促进血小板的粘附、聚集和释放,是冠心病形成及发展过程中的重要危险因素

    【关键词】血尿酸;冠心病;血小板最大聚集率

    The correlation with coronary heart diaease and effects on platelet aggregation function of serum uric acid

    ZHONG Wei wen,HONG Shu hui.

    Depantment of Cardiology,The 2 nd hospital of Shantou,Shantou 515000,China

    【Abstract】 Objective To discuss the correlation with coronary heart diaease and effects on platelet aggregation function of serum uric acid(SUA).Methods 120 patients diagnosed as suspected coronary heart disease were divided into two groups coronary heart diaease group(85cases)and normal control group(35 cases)according to coronary angiography.Comparing the differences of SUA level and Maximum platelet aggregation rate(MPAR).Besides,the coronary heart disease with high SUA patients were interfered with allopurinol for 4 weeks.Analysing the changes of SUA level and MPAR before and after treatment.Results The SUA level and MPAR of the former group were significantly higher(P<0.05)than the latter group.Single factor correlation analysis showed that uric acid levels and platelet aggregation rate were positively correlated(r =0.598,P<0.05)in coronary heart disease group.The SUA level and MPAR of coronary heart disease patients with hyperuricemia taking medicie were significantly lower than before treatment(P<0.05).The differences were statistically significant.Conclusion SUA can activate platelets and promote platelet adhesion,aggregation and release and was an important risk factor in the formation and development of coronary heart disease.

    【Key words】Serum uric acid ; Coronary heart disease; Maximum platelet aggregation rate

    冠心病的发生与多因素有关,新的危险因素被不断提出。高尿酸血症作为冠心病危险因素在近年来受到越来越多的关注。血小板活化及聚集功能增强是促进冠心病发生发展的重要机制之一。本研究旨在探讨血尿酸与冠心病的相关性及尿酸水平的变化对血小板聚集功能的影响。 ......

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