急性脑梗死患者颈动脉内膜中层厚度与血清高迁移率蛋白-1水平变化的意义(1)
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【摘要】 目的 探讨急性脑梗死患者颈总动脉平均内膜中层厚度(IMT)与血清高迁移率蛋白 1(HMGB1)的含量变化,及其在急性脑梗死发生过程中的作用和意义。方法 采用高分辨率彩色超声诊断仪测量颈动脉IMT,并采用酶联免疫法测定其血清HMGB1水平,并与60例年龄和性别相当的健康体检者(对照组)进行比较。结果 急性脑梗死患者颈动脉IMT和血清HMGB 1含量较两对照组显著升高;且IMT和血清HMGB1含量之间存在相关性(r=0.64,P<0.01)。结论 监测患者颈动脉IMT和血清HMGB1含量变化有助于预测脑梗死的发生。
【关键词】脑梗死; 高迁移率蛋白 1;颈动脉; 内膜 中层厚度
Relationship between the IMT of common carotidartery and the serum level of HMGB1 in patients with cerebral infarction
YIN Hai wei,ZHOU Yong qin,ZHANG Tao,et al.The Central People’s Hospital of Tengzhou,Shandong 277500,China
【Abstract】 Objective To investigate the relationship between the intima media thickness(IMT)of common carotidartery and the serum level of HMGB1 in patients with cerebral infarction.Methods The IMT of carotidartery were assessed by high resolution Doppler ultrasonography in 104 patients with with cerebral infarction and 60 healthy controls,and the serum HMGB1 was measured using ELISA,compared with those in 60 healthy subjects.Results The levels of the intima media thickness(IMT)of common carotidartery and serum HMGB1 of patients with cerebral infarction were markedly higher than those in the control groups.There was an obvious relationship between the intima media thickness(IMT)of common carotidartery and the level of serum HMGB1(r=0.64,P<0.01).Conclusion The level of serum HMGB1 and the intima media thickness(IMT)of common carotidartery had instructive significance in acute cerebral infarction treating and prognosis estimating.
【Key words】Cerebral infarction; Highmobility groupbox 1(HMGB1); Carotidartery; Intima media thickness(IMT)
颈动脉内膜中层厚度(IMT)增加是预测心脑血管患病率及死亡率的独立危险因素,测量颈动脉IMT可作为早期动脉粥样硬化可靠的评价指标[1]。高迁移率族蛋白 1(high mobility group protein 1,HMGB1)是近年发现的一种重要的晚期炎症介质,在炎症反应过程中表达升高较晚,维持时间较长,与组织损伤后修复。炎症反应及动脉粥样硬化等方面密切[2]。本研究旨在探讨二者之间的关系,为动脉粥样硬化及缺血性心脑血管病的早期干预提供相关依据。
1 资料与方法
1.1 对象选择 急性脑梗死患者104例,为2008年5月至2009年12月期间在我院急诊科和神经康复科住院患者。诊断符合全国第四届脑血管病学术会通过的脑梗死诊断标准[3]并经头颅CT或MRI证实。排除炎症、肿瘤和急性心肌梗死及近期心绞痛发作等。急性脑梗死(发病6 h内)102例,平均(68.5±2.3)岁。病情程度按脑卒中患者临床神经功能缺损程度评分标准[3]分为3组:轻型组(0~15分)38例中型组(16~30分)34例,重型组(31~45分)32例。
对照组60名,平均(68.1±2.5)岁。来自健康体检者,平时无头晕、头痛等不适,同时剔除严重肝、肾功能不全及各种急慢性感染性疾病,无肥胖、高血压、冠心病、糖尿病、甲状腺功能异常、肿瘤等病史。2组研究对象在年龄、性别比例、体重指数、吸烟、血压等方面具有可比性。
1.2 颈动脉B超检查 由固定2人操作,采用东芝PV 6000彩色超声诊断仪,探头频率7 ......
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