乌鲁木齐地区维族汉族多发性骨髓瘤对比分析(1)
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【摘要】 目的 探讨分析乌鲁木齐地区维族汉族多发性骨髓瘤特征。方法 对60例MM患者血清进行血清蛋白电泳、血清免疫固定电泳、尿本周氏蛋白电泳、流式细胞术的检测。结果 60例MM患者血清蛋白电泳显示M带31例(维族18例、汉族13例),主要位于γ区;免疫固定电泳分型:IgG、IgA、IgM、游离型,维族、汉族相应的分别为(8,16)、(6,9)、(1,5)、(11,4)例;尿本周氏蛋白检测17例阳性(维族11例,汉族6例);流式分析与汉族MM患者相比,维族男性MM患者CD3细胞、CD4细胞、CD4/CD8比值及B细胞均明显减少(P<0.05),而CD8细胞、NK细胞比例升高;维族女性MM患者CD3细胞、CD4细胞、CD4/CD8比值、NK细胞、B细胞比例均低于汉族MM患者,而CD8细胞比例显著高于汉族MM患者(P<0.05)。结论 乌鲁木齐地区MM患者存在民族、类别、免疫表型的差异。
【关键词】多发性骨髓瘤;免疫固定;免疫表型;流式细胞术
The compared analysis of Multiple Myeloma of Uygur and Han people in Urumqi Region
GUO Shu-li,TIAN Yong-fang,MA Hui-xia.
Department of Clinical Laboratory,the People’s Hospital of Urumqi,Xin Jiang 830001,China
【Abstract】 Objective To analyze contrastly the typical features of Multiple Myeloma of Uygur and Han people in Urumqi region in Xin Jiang.Methods We have detected the serum of 60 cases by serum protein electrophoresis,immunofixation electrophoresis,Bence Jones protein electrophoresis,and flow cytometry(FCM).Results Monoclone protein peak was found in 31out of 60 cases tested(18 cases were Uygur people and 13 cases were Han people),it located mainly γ border.The cases of Immunoglobulin G,Immunoglobulin A,Immunoglobulin M,free light chain was found in Uygur people and Han people were(8,16),(6,9),(1,5),(11,4),1respectively.Bence Jones protein electrophoresis detected 17 cases were positive(11cases were Uygur and 6 cases were Han people).Compared with the Multiple Myeloma of Han people,the percentage of the CD3,CD4,B cell,CD4/CD8 were reduced(P<0.05)and the percentage of the CD8 and NK increased in male Uygur patients.While all parameters except CD8 cells which was reduced in the female Multiple Myeloma of Uygur,and the percentage of the CD8 increased obviously(P<0.05).Conclusion It was found that characteristics of Multiple Myeloma in Urumqi,including nationality,category,and immunophenotype.
【Key words】Multiple Myeloma; Immunofixation electrophoresis; Immunophenotype; Flow cytometry
多发性骨髓瘤(multiple myeloma,MM)又名浆细胞骨髓瘤,是以克隆性恶性浆细胞(骨髓瘤细胞)在骨髓中异常增殖,并伴有单克隆免疫球蛋白增多为特征的疾病[1] ......
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