不同剂量阿托伐他汀对急性心肌梗死患者早期炎症反应的临床研究(1)
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【摘要】 目的 探讨不同剂量阿托伐他汀早期干预治疗对急性心肌梗死患者血脂及血清高敏C反应蛋白的影响。方法 60例AMI患者随机分为大剂量阿托伐他汀(40 mg/d)治疗组(30例)和常规剂量阿托伐他汀(20 mg/d)治疗组(30例),分别在入院24 h内及服药后3、7 d测定患者血脂、高敏C反应蛋白,比较两组患者血脂、高敏C反应蛋白的变化。结果 治疗7 d后20 mg/d及40 mg/d阿托伐他汀治疗组总胆固醇、低密度脂蛋白水平较治疗前有降低(P<0.05),而且40 mg/d阿托伐他汀治疗组高敏C反应蛋白水平显著降低,与20 mg/d阿托伐他汀治疗组比较有显著差异(P<0.01),而治疗前后两组间总胆固醇、低密度脂蛋白比较无统计学意义(P>0.05)。结论 早期大剂量阿托伐他汀应用更能降低急性心肌梗死患者的高敏C反应蛋白水平,且阿托伐他汀的抗炎治疗独立于降脂之外。
【关键词】 阿托伐他汀;血脂;高敏C反应蛋白;急性心肌梗死
The Clinical study of atorvastatin therapy of different doses on hs-CRP leves in patients in early phase with acute myocardial infarction
HUANG Qi-lei,WANG Guang-you,JIANG Ling.Department of Cardiology,Fujian Medical University Affiliated Teaching Hospital,Nanping First Hospital,Nanping 35300,China
【Abstract】 Objective To investigate the effect of different doses of atorvastatinon on serum high sensitivity C-reactive protein and blood lipid levels in early phase of acute myocardial infarction.Methods A total of 60 patients with AMI were randomly assigned into the large dosage of atorvastatin(40 mg/d)group(n=30)and the routine dosage ofatorvastatin(20 mg/d)(n=30).Serum levels of blood lipid,hs-CRP were measured with biochemistry assay 24 hour after admission and 3 days and 7 days after therapy.The difference in blood lipid,hs-CRP was compared between the two groups.Results Among the two groups,the levels of TC and LDL-C decreased significandy after treatment(P<0.05),in the large dosage of atorvastatin group,the levels of hs-CRP decreased significandy comparing with the routine dosage of atorvastatin group(P<0.01),but no visible statistic differences were found in TC,and LDL-C among the two groups.Conclusion Effect of early atorvastatin therapy of the large dosage on serum hs-CRP leves is better than the routine dosage in patients with acute myocardial infarction.The anti-inflammatory effect of atorvastatin is not related to lipid lowering.
【Key words】 Atorvastatin;Blood lipid;High sensitivity C-reactive protein;Acute myocardial infarction
研究表明,炎症反应在急性心肌梗死(acute myocardial infarction,AMI)的发生、发展过程中起着重要作用 ......
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