经皮冠状动脉介入治疗急性心肌梗死过程中超敏C-反应蛋白的动态观察(1)
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【摘要】 目的 观察经皮冠脉介入治疗急性心肌梗死(AMI)患者血清高敏C-反应蛋白(hs-CRP)的动态变化规律。方法 选择60例确诊急性心肌梗死患者于发病6 h内行急诊经皮冠脉介入治疗为介入组,用免疫比浊法分别测定所有患者冠状动脉介入治疗(PCI)术前、即刻、术后6、12、24、72 h及7 d hs-CRP水平,同时30例健康体检者为正常对照,并进行统计学分析。结果 PCI组介入治疗后AMI患者血浆hs-CRP水平随时间逐渐升高,在术后72 h上升至高峰值,并于7 d后恢复至术后12 h 水平,术后6、12、24、72 h及7 d hs-CRP水平显著高于正常对照组(P<0.05),术后72 h高峰值与其他时间点比较均有显著性差异(P<0.05)。结论 经皮冠脉治疗急性心肌梗死患者,发病后短期hs-CRP水平随时间呈动态变化,可作为PCI治疗AMI疗效观察指标之一。
【关键词】 心肌梗死;超敏C-反应蛋白;经皮冠状动脉介入治疗
Dynamic Observation on High-sensitivity C-reactive Protein in Acute Myocardial Infarction After Percutaneous Coronary Intervention
TIAN Yong-fang,XING Shu-qing,MO Hong-mei.Department of Laboratory Medicine,Department of endocrine,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China
【Abstract】 Objective To observe the dynamic change of high-sensitivity C-reactive protein(hs-CRP)after percutaneous coronary intervention(PCI)within 6 hours after attack of acute myocardial infarction(AM I).Methods The hs-CRP levels in serum was detected in 60 AMI patients within 6 hours after attack with immunoturbidimetry before PCI,at the opint of operation,6 h,12 h,24 h,72 h and 7 d after PCI.30 healthy examinationer were chosen as normal control.The two groups were compared with statistics.Results Thehs-CRP levels were increased gradually with time in AMI patients after PCI.The peak value was at 72 h after PCI and recovered to the level of 12 h after PCI at 7 d after PCI.The hs-CRP levels at 6 h,12 h,24 h,72 h and 7 d were significantly higher than those in the normal group(P<0.05),and hs-CRP at 72 h were significant higher than those at other opints(P<0.05).Conclusion The hs-CRP levels in short time after attack of AMI with PCI presented an dynamic changing and it can be one of the indexes on curative effect on AMI with PCI.
【Key words】 Acute Myocardial Infarction;High-sensitivity C-reactive Protein;Percutaneous Coronary Intervention
超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)是肝脏在受到炎性递质白介素(IL-6)刺激后合成分泌的一种经典急性时相反应蛋白,是一种非常敏感的炎症和组织损伤标记物,也是影响冠心病发病和预后的重要危险因素[1,2],冠状动脉介入治疗(PCI)急性心肌梗死患者,在改善其冠状动脉血流的同时,AMI患者血清hs-CRP水平在PCI治疗过程中的变化规律如何,本文拟对此进行探讨 ......
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