复方丹参注射液治疗急性胰腺炎的临床研究(1)
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【摘要】 目的 观察复方丹参注射液在治疗急性胰腺炎中的临床疗效,了解复方丹参注射液对急性胰腺炎(AP)患者血浆内皮素(ET)浓度的影响,对改善微循环的作用。方法 将100例AP患者随机分为对照组(40例)和治疗组(60例),对照组采用常规治疗,治疗组采用常规治疗+复方丹参注射液治疗,以放射免疫法(RIA)测定血浆ET浓度。结果 两组病例除了腹痛消失时间无显著性差异外(P>0.05),腹部压痛消失、血尿淀粉酶、影像学恢复和平均治疗时间治疗组均短于对照组(P<0.05)。治疗7 d后,对照组患者血浆ET浓度与治疗前比较无显著性差异;治疗组患者治疗后血浆ET浓度[(61.89±7.14)ng/L]显著低于治疗前[(104.41±7.88),P<0.05]。结论 在常规治疗的基础上应用复方丹参注射液治疗急性胰腺炎可以使患者微循环状态得到改善,具有良好的临床疗效。
【关键词】 急性胰腺炎;内皮素;复方丹参注射液
The Clinical Study on CO.SalviaMiltiorthizae.Injection in the Treatment of Actute Pancreatitis
ZHANG Jin-tang, ZOU Jin-lin.The Fifth Affiliated Hospital of Sun Yet-Sen University,Zhuhai 519000,China
【Abstract】 Objective To study clinical effects ofCO.SalviaMiltiorthizae(CSM) on Actute Pancreatitis,the changes of plasma endothelin(ET) as well as the role on the microcirculation of patients with acute pancreatitis(AP).Methods A total of 100 patients with AP was divided into contrast group (group A)(n=40)and treat treatment group(group B) (n=60),treated with routine method(group A)and CO.SalviaMiltiorthizae.injection added routine method,respectively.The levels of plasma ET were measured by radioimmunoassay.Results The average time of abdomen tenderness,amylase and shaperesume natural and treatment were significantly shorter in group B than in group A,but the average time of bellyache evaporating were notsignificantlydifferentialin the two groups.After 7 days treatment,the levels of ET in group A were slightly decreased compared with those before treatment(P>0.05),while the levels of ET in group B were obviously decreased compared with those be fore treatment[(61.89±7.14)ng/L vs (104.41±7.88)ng/L,P<0.05].Conclusion CSM and apply routine treatment used at the same time to treat AP can improvemicrocirculation disorder in pathogenesis of AP.There were well clinical effects.
【Key words】Acute pancreatitis;Endothelin; CO.SalviaMiltiorthizae injection
急性胰腺炎(AP)发病机制复杂,病情多变。近年来, 微循环障碍在急性胰腺炎发病机制中的作用越来越来受到重视。内皮素(ET)是目前作用最强烈的血管收缩物质,与AP微循环障碍发生及恶化关系密切。本文目的在于探讨静脉滴注复发丹参注射液联合常规治疗胰腺炎手段对急性胰腺炎治疗的临床疗效。现报告如下 ......
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