冠心病患者血小板活性与高敏C反应蛋白的关系(1)
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【摘要】 目的 探讨冠心病患者血小板活化膜糖蛋白GpⅡb/Ⅲa、P-selectin(P-选择素)的变化及其与高敏C反应蛋白(hs-CRP)的关系。方法 用三色全血流式细胞术测定40例冠心病患者外周血中血小板GPⅡb/Ⅲa、P-selectin的表达水平,并检测患者hs-CRP水平,与30例健康对照者比较。结果 冠心病组GpⅡb/Ⅲa、P-selectin、hs-CRP均高于健康对照组(均 P<0.001)。冠心病组GPⅡb/Ⅲa与hs-CRP呈正相关(r=0.45,P<0.005),P-selectin与hs-CRP呈正相关(r=0.59,P<0.001)。结论 冠心病患者血清hs-CRP增加、血小板明显活化,其血小板活化程度与hs-CRP关系密切。
【关键词】 冠状动脉疾病; 血小板活化; 高敏C反应蛋白
Therelation between platelet activation and hs-CRP in patients with coronary artery disease
TAN Jie,ZHANG Hong-yu,TANG Yu-xing.Departmen of Cardiology,the Fifth Affiliated Hospital of sun yat-sen University,Zhuhai 519000,China
【Abstract】 Objective To investigate the relationship among platelet membrane glucoproteins (GPⅡb/Ⅲa and P-selectin) and hs-CRP in patients with coronary artery disease.Methods Subjects were divided into 2 groups (40 patients with coronary artery disease,30cases of healthy subjects).Positive rates of PAC-1 and P-selectin were measured with tricolor flow cytometry.Hemorrheology was determined,and positive rates ofGPⅡb/Ⅲa and P-selectin were measured with tricolor flow cytometry.Hs-CRP levels were measured by nephelometry and turbidimetry in patients and normal controls.Results Compared with healthy group,hs-CRP levels and the expressions of both GPⅡb/Ⅲa、P-selectin were increased significantly in patients with coronary artery disease (all P<0.05).There is apositive correlation between the GPⅡb/Ⅲa、P-selectin and hs-CRP in patients with coronary artery disease.Conclusion The platelet in patients with coronary artery disease is at the overactivated state.Hs-CRP is involved in coronary artery disease.There is a relation between platelet activation and systemic inflammation in patients with coronary artery disease.
【Key words】Coronary artery disease; Platelet activation; Hs-CRP.
血小板活化与血管内皮细胞的损伤是血栓形成和进展的始发因素。GPⅡb/Ⅲa、P-selectin是活化血小板的特异性分子标志物,在血栓形成和放大过程中,在冠心病的发生、发展中起着非常重要的作用。冠心病与炎症的关系日益受到人们重视,越来越多的证据支持局部炎症或全身的炎症反应在动脉粥样硬化及其并发症的发生和发展中起到重要的作用。C反应蛋白(CRP)作为炎症反应的急性期蛋白之一于临床上被广泛应用,本试验用三色全血流式细胞术测定外周血中血小板GPⅡb/Ⅲa、P-selectin,用免疫比浊法测定高敏C反应蛋白(hs-CRP),探讨上述参数之间的相关性,以观察其在冠心病患者中的变化和临床价值 ......
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