高血压性心脏病患者血浆脂联素水平的变化(1)
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【摘要】 目的 探讨高血压性心脏病患者血浆脂联素水平的变化,为早期预防高血压心脏靶器官损害提供理论依据。方法 选择2007年10月至2008年5月在徐州市中心医院门诊或心内科住院的55例原发性高血压患者,分为两组:高血压组30例,高血压心脏病组25例。对照组为同期该院体检中心健康体健者40例。采用酶联免疫吸附法测定血浆脂联素含量。结果 血浆脂联素:高血压组(1050±310)ng/ml 显著低于正常组(2050±450)ng/ml(P<0.01),高血压心脏病组(650±136)ng/ml显著低于高血压组(P<0.01)与正常组(P<0.01)。结论 血浆脂联素水平的变化与原发性高血压的病情程度密切相关。
【关键词】高血压性心脏病;脂联素;原发性高血压
The plasma concentrations of adiponectin in patients with hypertensive heart disease
PANG-Hui,GONG Hai-bin,HUANG Wen-li,et al.Cardiovascular Disease Institute of Xuzhou,Central Hospital of Xuzhou 221009,China
【Abstract】 Objective To investigate the variation of plasma concentrations of adiponectinin patients with hypertensive heart disease which can be to provide theoretic evidence for early prevention and treatment of the hypertensives with target organ damage.Methods The study enrolled 55 patients with essential hypertension,who had visited the Central Hospital of Xuzhou from October 2007 to May 2008.These patients were divided into two groups:hypertension group included 30 patients and hypertensive heart disease group included 25 patients.40 cases of healthy individuals served as control group.All the patients,the plasma concentrations of adiponectin were measured by enzyme-linked immunosorbent assay(ELISA).Results The level of adiponectin in patients hypertension(1050±310)ng/ml was significantly lower than the control group(2050±450)ng/ml(P<0.01).That of the hypertensive patients with target organ damage group(650±136)ng/ml was significantly lower than the hypertension group(P<0.01)and the control group(P<0.01).Conclusion These results suggest that the level of adiponectin is associated with the course of the patients with essential hypertension,which may contribute to essential hypertension accident as a better predictor of risk.
【Key words】
Hypertensive heart disease; Adiponectin; Essential hypertension
脂联素是一种由脂肪组织分泌的胶原样蛋白,其能促进脂肪酸氧化和葡萄糖摄取、减少脂肪酸合成、降低糖异生过程中分子的表达,具有抗动脉粥样硬化、改善胰岛素抵抗、降血糖、抗炎等作用。脂联素是体内唯一与体脂含量呈负相关的脂肪因子,翻译后可修饰成8种异构体[1],其表达受多种激素的调控。本研究旨在探讨高血压性心脏病患者血浆脂联素水平的变化,为早期防治高血压心脏靶器官损害提供理论依据 ......
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