86例胃肠间质瘤的生物学特点与病理特征的关系分析(3)
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总之,本文证实胃和小肠是GIST最常见的发病部位,恶性GIST有增多的趋势。本组GIST的发病部位和良恶性程度与年龄、性别无关,但肿瘤恶性程度与肿瘤大小、核分裂数密切相关,并且随着肿瘤恶性程度的增加,肿瘤最大径和核分裂数随之增加。高度恶性肿瘤组中小肠和肠系膜网膜的比例较良性肿瘤组明显增多,临床应高度重视小肠和肠系膜网膜GIST的诊断和治疗。免疫组化指标CD117、 CD34、 SMA和 S100有助于GIST的鉴别诊断,GIST诊断时应重点观察肿瘤组织学形态特征,同时联合应用免疫标记来确定诊断。
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